Balancing the Osteogenic and Antibacterial Properties of Titanium by Codoping of Mg and Ag: An in Vitro and in Vivo Study

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• 作者：Yaochao Zhao ; Huiliang Cao ; Hui Qin ; Tao Cheng ; Shi Qian ; Mengqi Cheng ; Xiaochun Peng ; Jiaxin Wang ; Yin Zhang ; Guodong Jin ; Xianlong Zhang ; Xuanyong Liu ; Paul K Chu
• 刊名：ACS Applied Materials & Interfaces
• 出版年：2015
• 出版时间：August 19, 2015
• 年：2015
• 卷：7
• 期：32
• 页码：17826-17836
• 全文大小：885K
• ISSN：1944-8252

文摘

To simultaneously enhance the osteogenic and antibacterial properties of titanium, we introduced magnesium (Mg), silver (Ag), or both by using the plasma immersion ion implantation (PIII) technique, producing three PIII sample groups, namely, Mg-doped titanium (Mg鈥揚III), Ag-doped titanium (Ag鈥揚III), and Mg and Ag codoped titanium (Mg/Ag鈥揚III). The in vitro antibacterial efficacy of Mg/Ag鈥揚III group was about 7鈥?0% higher than that of Ag鈥揚III. In vitro and in vivo results demonstrated that osteogenic property of Mg/Ag PIII group was better than that of Ag鈥揚III or Mg鈥揚III. It was believed that the galvanic effects between Mg and Ag NPs played a key role in facilitating the release of Mg but reducing the release of silver, answering for the selective performances of the Mg/Ag鈥揚III group over bacterial and mammalian cells. This study demonstrated that the integration of multiple functional elements could be realized by the dual-source PIII technique, and in this case, the antibacterial properties and osteogenic property of titanium could be balanced.