Facile Protocol for Water-Tolerant 鈥淔rustrated Lewis Pair鈥?Catalyzed Hydrogenation

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• 作者：Daniel J. Scott ; Trevor R. Simmons ; Elliot J. Lawrence ; Gregory G. Wildgoose ; Matthew J. Fuchter ; Andrew E. Ashley
• 刊名：ACS Catalysis
• 出版年：2015
• 出版时间：September 4, 2015
• 年：2015
• 卷：5
• 期：9
• 页码：5540-5544
• 全文大小：349K
• ISSN：2155-5435

文摘

Despite rapid advances in the field of metal-free, 鈥渇rustrated Lewis pair鈥?(FLP)-catalyzed hydrogenation, the need for strictly anhydrous reaction conditions has hampered wide-scale uptake of this methodology. Herein, we report that, despite the generally perceived moisture sensitivity of FLPs, 1,4-dioxane solutions of B(C₆F₅)₃ actually show appreciable moisture tolerance and can catalyze hydrogenation of a range of weakly basic substrates without the need for rigorously inert conditions. In particular, reactions can be performed directly in commercially available nonanhydrous solvents without subsequent drying or use of internal desiccants.