Palladium-Catalyzed Aerobic Aminooxygenation of Alkenes for Preparation of Isoindolinones

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• 作者：Xuezhen Kou ; Yu Li ; Liang Wu ; Xinghua Zhang ; Guoqiang Yang ; Wanbin Zhang
• 刊名：Organic Letters
• 出版年：2015
• 出版时间：November 20, 2015
• 年：2015
• 卷：17
• 期：22
• 页码：5566-5569
• 全文大小：455K
• ISSN：1523-7052

文摘

A palladium-catalyzed intramolecular isoindolinone-forming aminooxygenation of alkenes with 1 atm of oxygen as oxidant is reported. A variety of functionalized alkenes and carboxylic acids can be used, and high yields were observed. Preliminary mechanistic studies revealed that the aminooxygenation products were formed through the oxidation of a C鈥揚d^II species using a strong oxidant, peroxide, which is generated in situ from a Pd(OAc)₂/bpy/O₂/HOAc catalytic system.