Copper-Catalyzed Phosphonation鈥揂nnulation Approaches to the Synthesis of 尾-Phosphonotetrahydrofurans Involving C鈥揚 and C鈥揙 Bonds Formation

详细信息    查看全文

• 作者：Yuzhen Gao ; Xueqin Li ; Weizhu Chen ; Guo Tang ; Yufen Zhao
• 刊名：Journal of Organic Chemistry
• 出版年：2015
• 出版时间：November 20, 2015
• 年：2015
• 卷：80
• 期：22
• 页码：11398-11406
• 全文大小：462K
• ISSN：1520-6904

文摘

Substituted tetrahydrofuran derivatives play important roles as biological activities. A versatile method for the synthesis of 尾-phosphonotetrahydrofurans has been developed based on Cu-catalyzed difunctionalization of alkenes. This transformation would provide a new pathway for the formation of Csp³鈥揚 and Csp³鈥揙 bonds in one step. Furthermore, this copper catalyst system can be used in the synthesis of 尾-phosphonotetrahydropyrans and phosphono-纬-butyrolactones. These reactions were also performed well by using 3 equiv of Mn(OAc)₃路2H₂O as the oxidant without copper catalyst.