Characterization of a Brain Permeant Fluorescent Molecule and Visualization of A尾 Parenchymal Plaques, Using Real-Time Multiphoton Imaging in Transgenic Mice

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• 作者：G.S.M. Sundaram ; Kanchan Garai ; Nigam P. Rath ; Ping Yan ; John R. Cirrito ; Nigel J. Cairns ; Jin-Moo Lee ; Vijay Sharma
• 刊名：Organic Letters
• 出版年：2014
• 出版时间：July 18, 2014
• 年：2014
• 卷：16
• 期：14
• 页码：3640-3643
• 全文大小：294K
• ISSN：1523-7052

文摘

Emerging paradigms mandate discovery of imaging agents for diagnosing Alzheimer鈥檚 disease (AD) prior to appearance of clinical symptoms. To accomplish this objective, a novel heterocyclic molecule (4) was synthesized and validated as A尾 targeted probe. The agent shows labeling of numerous diffuse A尾 plaques in confirmed AD human brain tissues and traverses the blood鈥揵rain barrier to enable labeling of parenchymal A尾 plaques in live mice (APP^卤/PS1^卤) brains.