An Asymmetric Synthesis of trans-Fused Butyrolactones from Endoperoxides

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• 作者：Joshua Priest ; Mark. R. Longland ; Mark R. J. Elsegood ; Marc C. Kimber
• 刊名：The Journal of Organic Chemistry
• 出版年：2013
• 出版时间：April 5, 2013
• 年：2013
• 卷：78
• 期：7
• 页码：3476-3481
• 全文大小：329K
• 年卷期：v.78,no.7(April 5, 2013)
• ISSN：1520-6904

文摘

The intermolecular addition of 1,3-dicarbonyl equivalents to endoperoxides in the presence of an organocatalyst yields trans-fused butyrolactones in high yield and enantioselectivities. This methodology expands the synthetic utility of endoperoxides and further underlines their potential as sources of oxygen functionality for natural and non-natural product target synthesis.