Insights into the Mechanisms of Amyloid Formation of ZnII-Ab11-28: pH-Dependent Zinc Coordination and Overall Charge as Key Parameters for Kinetics and the Structure of ZnII-Ab11

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• 作者：Bruno Alies ; Giovanni LaPenna ; St茅phanie Sayen ; Emmanuel Guillon ; Christelle Hureau ; Peter Faller
• 刊名：Inorganic Chemistry
• 出版年：2012
• 出版时间：July 16, 2012
• 年：2012
• 卷：51
• 期：14
• 页码：7897-7902
• 全文大小：379K
• 年卷期：v.51,no.14(July 16, 2012)
• ISSN：1520-510X

文摘

Self-assembly of amyloidogenic peptides and their metal complexes are of multiple interest including their association with several neurological diseases. Therefore, a better understanding of the role of metal ions in the aggregation process is of broad interest. We report pH-dependent structural and aggregation studies on Zn^II binding to the amyloidogenic peptide Ab11-28. The results suggest that coordination of the N-terminal amine to Zn^II is responsible for the inhibition of amyloid formation and the overall charge for amorphous aggregates.