Catalytic Asymmetric Synthesis of Optically Active Allenes from Terminal Alkynes

详细信息    查看全文

• 作者：Juntao Ye ; Suhua Li ; Bo Chen ; Wu Fan ; Jinqiang Kuang ; Jinxian Liu ; Yu Liu ; Bukeyan Miao ; Baoqiang Wan ; Yuli Wang ; Xi Xie ; Qiong Yu ; Weiming Yuan ; Shengming Ma
• 刊名：Organic Letters
• 出版年：2012
• 出版时间：March 2, 2012
• 年：2012
• 卷：14
• 期：5
• 页码：1346-1349
• 全文大小：823K
• 年卷期：v.14,no.5(March 2, 2012)
• ISSN：1523-7052

文摘

CuBr and ZnI₂ have been developed as catalysts or subcatalysts for the efficient asymmetric synthesis of axially chiral allenols with up to 97% ee from readily available propargylic alcohols, aliphatic or aromatic aldehyde, pyrrolidine, and commerically available ligands. The alcohol unit in the terminal alkynes plays a very important role for ensuring high enantioselectivity via coordination.