Facile Synthesis of Azaarene-Substituted 3-Hydroxy-2-oxindoles via Br酶nsted Acid Catalyzed sp3 C鈥揌 Functionalization

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• 作者：Rui Niu ; Jian Xiao ; Tao Liang ; Xingwei Li
• 刊名：Organic Letters
• 出版年：2012
• 出版时间：February 3, 2012
• 年：2012
• 卷：14
• 期：3
• 页码：676-679
• 全文大小：789K
• 年卷期：v.14,no.3(February 3, 2012)
• ISSN：1523-7052

文摘

Br酶nsted acid catalyzed functionalization of sp³ C鈥揌 bonds in 2-methyl azaarenes has been achieved in the reaction with isatins. This method provides facile synthesis of biologically important azaarene-substituted 3-hydroxy-2-oxindoles in one step in moderate to good yields.