Palladium-Catalyzed Cycloaddition of Alkynyl Aryl Ethers with Internal Alkynes via Selective Ortho C鈥揌 Activation

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• 作者：Yasunori Minami ; Yuki Shiraishi ; Kotomi Yamada ; Tamejiro Hiyama
• 刊名：The Journal of the American Chemical Society
• 出版年：2012
• 出版时间：April 11, 2012
• 年：2012
• 卷：134
• 期：14
• 页码：6124-6127
• 全文大小：286K
• 年卷期：v.134,no.14(April 11, 2012)
• ISSN：1520-5126

文摘

Alkynyl aryl ethers react with internal alkynes through selective ortho C鈥揌 activation by a palladium(0) catalyst to give substituted 2-methylidene-2H-chromenes. The alkynoxy group acts as a directing group to promote ortho C鈥揌 functionalization. Deuterium-labeling experiments indicated that the arylpalladium hydride complex is a key intermediate via oxidative addition. Various functional groups tolerate the present transformation to give the corresponding products.