(±)-Aspongamide A, an N-Acetyldopamine Trimer Isolated from the Insect Aspongopus chinensis, Is an Inhibitor of p-Smad3

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• 作者：Yong-Ming Yan ; Jun Ai ; Yan-Ni Shi ; Zhi-Li Zuo ; Bo Hou ; Jie Luo ; Yong-Xian Cheng
• 刊名：Organic Letters
• 出版年：2014
• 出版时间：January 17, 2014
• 年：2014
• 卷：16
• 期：2
• 页码：532-535
• 全文大小：219K
• ISSN：1523-7052

文摘

(卤)-Aspongamide A (1), an unusual trimer of N-acetyldopamine (NADA) bearing a novel tetrahydrobenzo[a]dibenzo[b,e][1,4]dioxine structure, and a pair of NADA dimeric enantiomers (2) were isolated from Aspongopus chinensis. The structures of compounds 1 and 2 were assigned using spectroscopic methods. Compound 1 was found to be an inhibitor of Smad3 phosphorylation in transforming growth factor-尾1 (TGF-尾1) induced rat renal proximal tubular cells and suppressed extracellular matrix expression in mesangial cells under diabetic conditions.