Phyteumosides A and B: New Saponins with Unique Triterpenoid Aglycons from Phyteuma orbiculare L.

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• 作者：Christian Abbet ; Markus Neuburger ; Trixie Wagner ; Melanie Quitschau ; Matthias Hamburger ; Olivier Potterat
• 刊名：Organic Letters
• 出版年：2011
• 出版时间：March 18, 2011
• 年：2011
• 卷：13
• 期：6
• 页码：1354-1357
• 全文大小：688K
• 年卷期：v.13,no.6(March 18, 2011)
• ISSN：1523-7052

文摘

Phyteumosides A (1) and B (2), two saponins with unprecedented triterpenoid aglycons, were isolated from the aerial parts of Phyteuma orbiculare (Campanulaceae). Their structures were elucidated by spectroscopic and chemical methods and corroborated by X-ray diffraction analyses of the aglycons obtained through enzymatic hydrolysis. The aglycon of 1 can be considered as an incompletely cyclized onoceroid or gammaceroid triterpene with two additional tetrahydropyran rings arising from oxygen bridges. Compound 2 possesses a new 17-polypodene aglycon.