Cyclopeptide Alkaloids from Ziziphus apetala

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• 作者：Jing Han ; Chang-Jiu Ji ; Wen-Jun He ; Yu Shen ; Ying Leng ; Wen-Yan Xu ; Jun-Ting Fan ; Guang-Zhi Zeng ; Ling-Dong Kong ; Ning-Hua Tan
• 刊名：Journal of Natural Products
• 出版年：2011
• 出版时间：December 27, 2011
• 年：2011
• 卷：74
• 期：12
• 页码：2571-2575
• 全文大小：235K
• 年卷期：v.74,no.12(December 27, 2011)
• ISSN：1520-6025

文摘

Six novel Ia₃-type cyclopeptide alkaloids (1鈥?b>6) were isolated from stems of Ziziphus apetala. Compound 5 and the known compounds mauritine A (7) and mauritine F (8) were isolated from the roots. Their structures were determined by spectroscopic analyses and chemical methods. The total alkaloids from the roots and the isolated cyclopeptide alkaloids were tested for antidepressant behavior on mice, cytotoxicity, and 11尾-hydroxysteroid dehydrogenase (11尾-HSD) inhibition in vitro. Only mauritine A (7) showed inhibitory activity on 11尾-HSD1, with IC₅₀ values of 52.0 (human) and 31.2 渭g/mL (mouse).