Photoelectrochemical detection of pentachlorophenol with a Multiple Hybrid CdSexTe1−x/TiO2 Nanotube Structure-Based Label-Free Immunosensor

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• 作者：Qing Kang ; Lixia Yang ; Yufang Chen ; Shenglian Luo ; Lingfei Wen ; Qingyun Cai ; Shouzhuo Yao
• 刊名：Analytical Chemistry
• 出版年：2010
• 出版时间：December 1, 2010
• 年：2010
• 卷：82
• 期：23
• 页码：9749-9754
• 全文大小：292K
• 年卷期：v.82,no.23(December 1, 2010)
• ISSN：1520-6882

文摘

Driven by the urgent demand of detecting trace amounts of pentachlorophenol (PCP) in contaminative water, a label-free immunosensor with ultra sensitivity and high selectivity was constructed based on a hybrid CdSe_xTe_1−x (0 ≤ x ≤ 1) nanocrystal (NCs)-modified TiO₂ nanotube (NT) arrays for the first time. The CdSe_xTe_1−x NCs were photoelectrodeposited on inner and outer space of the TiO₂ NTs, leading to high photoelectrical conversion efficiency in the visible region. PCP antibodies are covalently conjugated on the TiO₂ NTs due to the large surface area and good biocompatibility. Since the photocurrent is highly dependent on the TiO₂ surface properties, the specific interaction between PCP and the antibodies results in a sensitive change in the photocurrent, with a limit of detection (LOD) of 1 pM. High sensor-to-sensor reproducibility is achieved. The sensor was applied for the direct analysis of river water samples.