Spatially Controlled Suzuki and Heck Catalytic Molecular Coupling

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• 作者：Jason J. Davis ; Claire B. Bagshaw ; Katerina L. Busuttil ; Yuki Hanyu ; Karl S. Coleman
• 刊名：Journal of the American Chemical Society
• 出版年：2006
• 出版时间：November 1, 2006
• 年：2006
• 卷：128
• 期：43
• 页码：14135 - 14141
• 全文大小：922K
• 年卷期：v.128,no.43(November 1, 2006)
• ISSN：1520-5126

文摘

The initiation and control of chemical coupling has the potential to offer much within the contextof "bottom up" nanofabrication. We report herein the use of a palladium-modified, catalytically active, AFMprobe to initiate and spatially control surface-confined Suzuki and Heck carbon-carbon coupling reactions.These "chemically written reactions", detectable by lateral force and chemically specific optical andtopographic labeling, were patterned with line widths down to 15 nm or ~20 molecules. Catalyzedorganometallic coupling was, in this way, carried out at subzeptomolar levels. By varying the catalyst-substrate interaction times, turnover numbers of (0.6-1.2) × 10⁴ and (3.0-5.0) × 10⁴ molecules s^-1 wereresolved for Suzuki and Heck reactions, respectively.