Role of the Molecular Conformation in the Two- and Three-Dimensional Supramolecular Structure of 10 Hydroxyl-N-alkylamides

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• 作者：Concepció ; n Foces-Foces ; Mat&iacute ; as Ló ; pez-Rodr&iacute ; guez ; Cirilo Pé ; rez ; Julio D. Mart&iacute ; n ; Natalia Pé ; rez-Herná ; ndez
• 刊名：Crystal Growth & Design
• 出版年：2007
• 出版时间：May 2007
• 年：2007
• 卷：7
• 期：5
• 页码：905 - 911
• 全文大小：357K
• 年卷期：v.7,no.5(May 2007)
• ISSN：1528-7505

文摘

Sixteen new 7,7-dialkyl-5-hydroxymethyl-6-oxabicyclo[3.2.1]octane-1-carboxylic acid amide derivatives with thehydroxymethyl and the N-alkylamide functional groups in axial positions have been synthesized, and the solid-state structure of 10of them has been determined. All of them crystallized as anhydrous compounds, and the conformation of the hydroxyl and N-alkylamidesubstituents was found to be correlated with the types of interactions in which they are involved, generating two- and three-dimensionalhydrogen-bonding networks based on identical dimeric substructures in 8 of the 10 cases. This dimer can be considered as asupramolecular synthon for future crystal engineering studies.