X-ray Structure of Physiological Copper(II)-Bis(L-histidinato) Complex

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• 作者：Patrick Deschamps ; Prasad P. Kulkarni ; and Bibudhendra Sarkar
• 刊名：Inorganic Chemistry
• 出版年：2004
• 出版时间：May 31, 2004
• 年：2004
• 卷：43
• 期：11
• 页码：3338 - 3340
• 全文大小：51K
• 年卷期：v.43,no.11(May 31, 2004)
• ISSN：1520-510X

文摘

The isolation and the X-ray crystal structure of physiological copper(II)-L-histidine complex are reported. The neutral five-coordinatecomplex shows distorted square pyramidal geometry with bidentateand tridentate L-histidine ligands. The basic character of thependent imidazole group and H-bonding interactions of bidentateL-histidine ligand are important for copper transport. The uniquestructural features help explain the origin of its thermodynamic stability and kinetic reactivity in human blood along withthe ternary copper(II)-amino acid complexes. The role of L-histidinein interaction with copper(II)-albumin, in cellular uptake of copper,and in treatment of Menkes disease can be studied using theseresults.