The endocrine disrupting potential of monosodium glutamate (MSG) on secretion of the glucagon-like peptide-1 (GLP-1) gut hormone and GLP-1 receptor interaction

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• 作者：Maeve Shannon^a ; Brian Green^a ; Gary Willars^b ; Jodie Wilson^a ; Natalie Matthews^a ; Joanna Lamb^a ; Anna Gillespie^a ; Lisa Connolly^a ; ^{l.connolly@qub.ac.uk}
• 关键词：Monosodium glutamate ; In vitro bioassays ; High content analysis ; GLP-1 ; Diabetes ; Obesity
• 刊名：Toxicology Letters
• 出版年：2017
• 出版时间：4 January 2017
• 年：2017
• 卷：265
• 期：Complete
• 页码：97-105
• 全文大小：1387 K
• 卷排序：265

文摘

Monosodium glutamate (MSG) is a suspected obesogen. Endocrine disrupting effect of MSG on GLP-1 was assessed. Following 3 h exposure, MSG induced an increase in GLP-1 secretion. Following 72 h exposure, MSG caused a reduction in GLP-1 secretion. High content analysis assay highlighted pre-lethal cytotoxic effects of MSG.