Effects of pregabalin on spinal d-serine content and NMDA receptor-mediated synaptic transmission in mice with neuropathic pain

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• 作者：Eiko Kato ; Rie Matsuzawa ; Shunsaku Kobayashi ; Teruyuki Fukushima ; Masao Maekawa ; Yuuichi Hori ; ^{horiy@dokkyomed.ac.jp}
• 关键词：Pregabalin ; d-Serine ; NMDAR mediated synaptic current ; Spinal superficial dorsal horn ; Neuropathic pain ; Tight-seal whole-cell recording
• 刊名：Neuroscience Letters
• 出版年：2017
• 出版时间：1 January 2017
• 年：2017
• 卷：636
• 期：Complete
• 页码：270-275
• 全文大小：1322 K
• 卷排序：636

文摘

Pregabalin attenuated nerve injury-induced increases in spinal d-serine content. Pregabalin attenuated injury-induced increases in the NMDA/non-NMDA ratio of EPSCs. Pregabalin shortened prolonged NMDA-EPSC decay time induced by nerve injury. Bath-applied d-serine reversed pregabalin-induced effects on NMDA-EPSCs. Pregabalin decreases d-serine and alters synaptic plasticity in the dorsal horn.