Facile synthesis and antiproliferative activity of 7H-benzo[7,8]chromeno[2,3-d]pyrimidin-8-amines

详细信息    查看全文

• 作者：Hamidreza Akrami^a ; Maliheh Safavi^b ; Bibi Fatemeh Mirjalili^a ; Mahmood Dehghani Ashkezari^c ; Farhang Dadfar^c ; Najme Mohaghegh^a ; Saeed Emami^d ; Fahimeh Salehi^e ; Hamid Nadri^f ; Sussan K. Ardestani^e ; Loghman Firoozpour^g ; Mehdi Khoobi^h ; ⁱ ; ^{khoobi@tums.ac.ir} ; Alireza Foroumadi^g ; ^h ; ^{aforoumadi@yahoo.com}
• 关键词：Anticancer ; Cytotoxic agents ; Benzochromene ; Polycyclic compounds
• 刊名：European Journal of Medicinal Chemistry
• 出版年：2017
• 出版时间：15 February 2017
• 年：2017
• 卷：127
• 期：Complete
• 页码：128-136
• 全文大小：1554 K
• 卷排序：127

文摘

Some tetracyclic chromenopyrimidines were synthesized as potential anticancer agents. The cytotoxic activity was tested against A549, MOLT-4, and HeLa cell lines. 2-Fluoroaniline derivatives 6e and 6l showed superior activity on A549 and MOLT-4. The benzylamine analog 6h was the most potent compound against HeLa cells. Flow cytometric analyses showed that 6l can induce apoptosis in MOLT-4 cells.