An immunoradiometric assay was used to homochronously measure the serum CA19-9 and CEA levels in 78 pancreatic cancer cases and 64 healthy examinees in hospital. The normal reference values were CA19-9(0-39 U/ml) and CEA(0-3.4 ng/ml).
Mean serum CA19-9 and CEA levels in patients with pancreatic cancer(406.55 ± 60.18 U/ml, 12.43 ± 1.25 ng/ml) were significantly higher(P < 0.01) than those in healthy examinees(16.54 ± 1.95 U/ml, 2.37 ± 0.17 ng/ml). The sensitivity of the combined detection of CA19-9 and CEA (92.31 % ) was significantly higher(P < 0.05) than that of either marker alone (79.49 % , 71.79 % , respectively). In addition, the sensitivity to diagnose pancreatic cancer by detecting the serum CA19-9 and CEA levels was higher(P < 0.05) in stage, II B + III + IV(87.04 % , 79.23 % ) than stage I + II, A(62.50 % , 54.17 % ).
The combined detection of CA19-9 and CEA could overcome the deficiency of using single marker detection by improving the sensitivity to diagnose pancreatic cancer. At the same time, CA19-9 and CEA detection could be used to assess mesenteric artery invasion and the metastasis of lymphatics and distant organs in pancreatic cancer.
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