Hallmarks of Tissue-Resident Lymphocytes

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• 作者：Xiying Fan¹ ; ^{xif2003@med.cornell.edu" class="auth_mail" title="E-mail the corresponding author} ; Alexander Y. Rudensky¹ ; ² ; ^{rudenska@mskcc.org" class="auth_mail" title="E-mail the corresponding author}
• 刊名：Cell
• 出版年：2016
• 出版时间：10 March 2016
• 年：2016
• 卷：164
• 期：6
• 页码：1198-1211
• 全文大小：1121 K

文摘

Although they are classically viewed as continuously recirculating through the lymphoid organs and blood, lymphocytes also establish residency in non-lymphoid tissues, most prominently at barrier sites, including the mucosal surfaces and skin. These specialized tissue-resident lymphocyte subsets span the innate-adaptive continuum and include innate lymphoid cells (ILCs), unconventional T cells (e.g., NKT, MAIT, γδ T cells, and CD8αα⁺ IELs), and tissue-resident memory T (T_RM) cells. Although these diverse cell types differ in the particulars of their biology, they nonetheless exhibit important shared features, including a role in the preservation of tissue integrity and function during homeostasis, infection, and non-infectious perturbations. In this Review, we discuss the hallmarks of tissue-resident innate, innate-like, and adaptive lymphocytes, as well as their potential functions in non-lymphoid organs.