SR 141716A, a cannabinoid receptor antagonist, produces hyperalgesia in untreated mice

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• 作者：Richardson ; Jennelle Durnett ; Aanonsen ; Lin ; Hargreaves ; Kenneth M.
• 关键词：Cannabinoid ; Hyperalgesia ; Pain
• 刊名：European Journal of Pharmacology
• 出版年：1997
• 出版时间：January 29, 1997
• 年：1997
• 卷：319
• 期：2-3
• 页码：R3-R4
• 全文大小：186 K

文摘

Antinociceptive effects of cannabinoids are well documented. However, the physiological role of endogenous cannabinoids in nociception is unknown. We evaluated the effects of the cannabinoid receptor antagonist SR 141716A (N-piperidino-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-3-pyrazolecarboxamide) on mouse hot plate latencies. Intrathecal injection of SR 141716A evoked a significant thermal hyperalgesia. These results suggest that the cannabinoid system tonically regulates thermal nociceptive thresholds. Furthermore, the absence of this regulation results in hyperalgesia suggesting that hypoactivity of this system may be involved in certain types of chronic pain.