ChemInform Abstract: Organohalogenite-Catalyzed Spiroketalization: Enantioselective Synthesis of Bisbenzannulated Spiroketal Cores.

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• 作者：Jijun Xue ; Hongrui Zhang ; Tian Tian ; Keshu Yin ; Dongxue Liu ; Xianxing Jiang ; Ying Li ; Xiaojie Jin and Xiaojun Yao
• 刊名：ChemInform
• 出版年：2016
• 出版时间：May, 2016
• 年：2016
• 卷：47
• 期：24
• 全文大小：26K
• ISSN：1522-2667

文摘

A new core structure-motivated strategy for the intramolecular aromatic spiroketalization process is used for the enantioselective synthesis of bisbenzannulated spiroketals, the bioactive core of rubromycins, with high enantioselectivities (up to 98% e.e.) via an organohalogenite-mediated asymmetric intramolecular aromatic spiroketalization.