Identification and Mechanistic Studies of a Cell Cycle Regulator JP18 from a Library of Synthetic Indole Terpenoid Mimics

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• 作者：Jinpeng Pei ; Shupeng Zhou ; Fan Yang ; Yu Sun ; Prof. Dr. Ang Li ; Prof. Dr. Wei-Dong Zhang and Prof. Weiwei He
• 刊名：Chemistry – An Asian Journal
• 出版年：2016
• 出版时间：October 6, 2016
• 年：2016
• 卷：11
• 期：19
• 页码：2715-2718
• 全文大小：1285K
• ISSN：1861-471X

文摘

We constructed a small library of indole terpenoid mimics using a hybridizing strategy to link various indole and α,β-unsaturated enone building blocks together. Prepared compounds were evaluated for the cytotoxicity against a panel of cancer cell lines. An indolyl ketone called JP18 was identified as a cell cycle regulator, and the underlying mechanism was investigated.