The Qiongbulake copper deposit is the largest deposit in western Awulale Mountain copper belt of Xinjiang. Three ore types from No.1 ore body were selected for fluid inclusion and stable isotope studies. The results reveal that all the fluid inclusions are of L-V type and NaCl-H₂O system. Fluid inclusions associated with calcite display moderate-low homogenization temperatures(85℃～343℃), moderate-low salinities(1.57～17.79 wt%NaCl eq.) and low densities(0.7g/cm³～1.05 g/cm³). Therefore, the No.1 ore body is not of sedimentation-transformation genesis but of volcanic hydrothermal genesis. The mixing of volcanic hydrothermal solution and circulated meteoric water was probably responsible for ore genesis. The slow cooling of ore-forming fluid played the most important role in the deposition of minerals. However, the effect of dilution and the increase of pH were not negligible.