This paper reports a detailed C, O, S and Pb isotopic investigation of three SVR deposits(No.109, Qunjisayi and Qunji) and two ILTHV deposits(Nulasai and Qiongbulake) lying from south to north in the ore field. In conclusion, the systematic variations of mineral source and ore-forming process from SVR deposits to ILTHV deposits reveal that the metallogenic environments in southern and northern copper belt are different and this difference was probably related to the Permian rifting evolution.In the process of Permian rifting evolution, the different extents of the stretching structure in southern and northern copper belt caused different volcanic rocks and sedimentary strata which constituted the ore-source bed.The formation of different Cu deposit types in different positions was controlled by the difference in mineral sources and intensities of continental volcanism caused by the Permian rifting.