The Balkhash metallogenic belt in Kazakhstan, with many porphyritic Cu-Mo deposits and some quartz-vein greisen Mo-W deposits, is a famous porphyritic Cu-Mo metallogenic belt in Central Asian metallogenic domain. The geochronological data and thermal history modeling presented in this paper, together with metallogenic information from previous studies, reveal the entire thermo-history, from the intrusion of plutons and Mo-W metallogenesis in the abyssal system in the Late Carboniferous and the Early Permian, through regional cooling, to the exhumation of the deposits in the Late Cretaceous, in the western part of Balkhash metallogenic belt.