This paper reviews the progresses and existing problems of pyrite framboid’s studies during different study stages including the biogenesis’ theory stage (1923~1969), abiogenesis’ theory stage (1969-2000) and multiple genesis’s theory stage (2000~present) in terms of formation mechanism and the relationship with the environments. It also explores the prospects of pyrite framboid’s study, pointing out that pyrite framboid has a great potential as the indicator of the surface and deep biospheres, the extraterrestrial environments and life. And finally puts forward the proposal that the authors should further study pyrite framboid by integrating its studies in that of earth science, life science, materials science, chemistry, nanotechnology and condensed matter physics.