The Guanyinan lead-zinc deposit is located in the southeastern margin of the basement uplift between Hannan and Beiba at the northern margin of the Yangtze land-mass, belonging to the east extension along the dip direction of the east ore blocks of the Nananshan-Dongping lead-zinc deposit in the Mayuan lead-zinc ore zone. Based on analysis of ore-controlled conditions and creation of ore-prospecting model, it is suggested that ore-prospecting at depth in this area should be commenced along the uplift margin of basement to the outward brecciated dolomite horizon of the Dengying Formation at depth, the fractured and brecciated dolomite zone within a range between 10 m and 50 m under the parallel unconformity of ∈1/Z2 at the north margin of the Yangtze land-mass, in which the blind range in the Dengying Formation along the brecciate zone is the focal places and a great potential for ore-prospecting is in a deep part.