In this paper, the authors conducted a preliminary theoretical study on the REE migration in various minerals based on analyzing the constraint of crystal lattice configuration and ion type on elements diffusion, and a multivariate model was proposed for predicating diffusive parameters of REE in minerals under a dry, 1-atm condition. E and lnD0 data calculated in this paper using the multivariate model are in a good agreement with previous experimental data. Compared with the previous prediction models, the multivariate model proposed in this paper can comprehensively reflect the influences of various crystal chemical factors in diffusive system.