慢性牙周炎与IgA肾病相关性研究进展
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摘要
IgA肾病是原发性肾小球疾病中的常见类型,发病机制尚未明确,炎症与IgA肾病存在相关性,慢性牙周炎是与感染有关的多系统疾病,可能是IgA肾病的危险因素之一。本文就牙周炎与IgA肾病相关性的研究进展作一综述。
IgA nephropathy is a common type of primary glomerular disease with unclear pathogenesis,and inflammation has been confirmed to be involved.Being a multi-system disease associated with infection,chronic periodontitis might be one of the risk factors for IgA nephropathy.This paper reviews the research progress of the correlation between periodontitis and IgA nephropathy.
IgA nephropathy is a common type of primary glomerular disease with unclear pathogenesis,and inflammation has been confirmed to be involved.Being a multi-system disease associated with infection,chronic periodontitis might be one of the risk factors for IgA nephropathy.This paper reviews the research progress of the correlation between periodontitis and IgA nephropathy.
引文
[1]IOANNIDOU E,SWEDE H.Disparities in periodontitis prevalence among chronic kidney disease patients[J].J Dent Res,2011,90(6):730-734.
[2]阿孜古丽,刘健,桑晓红,等.慢性牙周炎与IgA肾病的相关性研究[J].中国全科医学,2014,17(5):524-526.
[3]PALMER S C,RUOSPO M,WONG G,et al.Patterns of oral disease in adults with chronic kidney disease treated with hemodialysis[J].Nephrol Dial Transplant,2016,31(10):1647-1653.
[4]TANAKA S,NINOMIYA T,KATAFUCHI R,et al.Development and validation of a prediction rule using the Oxford classification in IgA nephropathy[J].Clin J Am Soc Nephrol,2013,8(12):2082-2090.
[5]赫艳梅,金小玲.原发性IgA肾病患者血清尿酸水平变化及意义[J].中华实用诊断与治疗杂志,2014,28(7):727-728.
[6]LE W,LIANG S,HU Y,et al.Long-term renal survival and related risk factors in patients with IgA nephropathy:results from a cohort of 1155cases in a Chinese adult population[J].Nephrol Dial Transplant,2012,27(4):1479-1485.
[7]FLOEGE J,FEEHALLY J.The mucosa-kidney axis in IgAnephropathy[J].Nat Rev Nephrol,2016,12(3):147-156.
[8]戴晓玮,钟良军,朱涛.伴慢性牙周炎冠心病患者动脉粥样硬化斑块中牙龈卟啉单胞菌牙龈素基因片段检测[J].中华实用诊断与治疗杂志,2013,27(7):673-675.
[9]WALLER T,KESPER L,HIRSCHFELD J,et al.Porphyromonas gingivalis outer membrane vesicles induce selective tumor necrosis factor tolerance in a Toll-like receptor 4-and mTOR-dependent manner[J].Infect Immun,2016,84(4):1194-1204.
[10]OTENIO C C,FONSECA I,MARTINS M F,et al.Expression of IL-1β,IL-6,TNF-α,and iNOS in pregnant women with periodontal disease[J].Genet Mol Res,2012,11(4):4468-4478.
[11]TAN J,ZHOU L,XUE P,et al.Tumor necrosis factor-αattenuates the osteogenic differentiation capacity of periodontal ligament stem cells by activating PERK signaling[J].JPeriodontol,2016,87(8):159-171.
[12]CORTELA D C,DE SOUZA JUNIOR A L,VIRMOND M C,et al.Inflammatory mediators of leprosy reactional episodes and dental infections:a systematic review[J].Mediators Inflamm,2015:548540.
[13]BORAWSKI J,WILCZYNSKA-BORAWSKA M,STOKOWSKA W,et al.The periodontal status of pre-dialysis chronic kidney disease and maintenance dialysis patients[J].Nephrol Dial Transplant,2007,22(2):457-464.
[14]IOANNIDOU E,SWEDE H,DONGARI-BAGTZOGLOU A.Periodontitis predicts elevated C-reactive protein levels in chronic kidney disease[J].J Dent Res,2011,90(12):1411-1415.
[15]SCHMITT R,STAHL A L,OLIN A I,et al.The combined role of galactose-deficient IgA1and streptococcal IgA-binding M protein in inducing IL-6 and C3 secretion from human mesangial cells:implications for IgA nephropathy[J].JImmunol,2014,193(1):317-326.
[16]许志鹏,宋勇,孙燕.伴有牙周炎的IgA肾病患者牙周治疗前后血清TNF-α与IL-8变化分析[J].海南医学,2015,26(18):2681-2683.
[17]李静,李增录,桑晓红,等.慢性牙周炎与慢性肾衰竭动物模型中IL-1β的表达[J].中国中西医结合肾病杂志,2010,11(7):586-589.
[18]刘衍杰,李静,桑晓红,等.没食子提取物对IgAN大鼠尿液及肾组织IL-6表达的影响[J].中国中西医结合肾病杂志,2016,17(3):218-220.
[19]MAEKAWA T,ABE T,HAJISHENGALLIS E,et al.Genetic and intervention studies implicating complement C3as a major target for the treatment of periodontitis[J].J Immunol,2014,192(12):6020-6027.
[20]ABE T,HOSUR K B,HAJISHENGALLIS E,et al.Local complement-targeted intervention in periodontitis:proof-ofconcept using a C5a receptor(CD88)antagonist[J].JImmunol,2012,189(11):5442-5448.
[21]YOU Y K,HUANG X R,CHEN H Y,et al.C-reactive protein promotes diabetic kidney disease in db/db mice via the CD32b-Smad3-mTOR signaling pathway[J].Sci Rep,2016,6:26740.
[22]COPPO R,CAMILLA R,AMORE A,et al.Toll-like receptor4expression is increased in circulating mononudear cells of patients with immunoglobulin A nephropathy[J].Exp Irmnunol,2010,159(1):73-81.
[23]BORGNAKKE W S.Periodontitis may be associated with chronic kidney disease,but current evidence is insufficient[J].J Evid Base Dent Pract,2013,13(3):88-90.
[24]KSHIRSAGAR A V,GRUBBS V.Periodontal disease and CKD-associated morbidity:is there now enough evidence to move from observation to intervention?[J].Am J Kidney Dis,2015,66(2):181-183.
[25]曹娅丽,乔敏,徐志宏,等.IgA肾病患者合并慢性重度和侵袭性牙周炎的临床特点[J].中华医学杂志,2016,30(1):9-13.
[26]李静,张静,刘健,等.慢性牙周炎与IgA肾病复合动物模型的建立及相互关系[J].中华肾脏病杂志,2013,29(11):842-848.
[27]李团结,李静,刘健,等.大鼠CP与IgAN复合模型临床参数及病理改变的研究[J].口腔医学研究,2014,30(7):622-626.
[28]王丽娜,李静,刘健,等.大鼠慢性牙周炎与IgA肾病复合模型血清中MMP-3的表达及意义[J].口腔医学研究,2013,29(11):1034-1038.
[2]阿孜古丽,刘健,桑晓红,等.慢性牙周炎与IgA肾病的相关性研究[J].中国全科医学,2014,17(5):524-526.
[3]PALMER S C,RUOSPO M,WONG G,et al.Patterns of oral disease in adults with chronic kidney disease treated with hemodialysis[J].Nephrol Dial Transplant,2016,31(10):1647-1653.
[4]TANAKA S,NINOMIYA T,KATAFUCHI R,et al.Development and validation of a prediction rule using the Oxford classification in IgA nephropathy[J].Clin J Am Soc Nephrol,2013,8(12):2082-2090.
[5]赫艳梅,金小玲.原发性IgA肾病患者血清尿酸水平变化及意义[J].中华实用诊断与治疗杂志,2014,28(7):727-728.
[6]LE W,LIANG S,HU Y,et al.Long-term renal survival and related risk factors in patients with IgA nephropathy:results from a cohort of 1155cases in a Chinese adult population[J].Nephrol Dial Transplant,2012,27(4):1479-1485.
[7]FLOEGE J,FEEHALLY J.The mucosa-kidney axis in IgAnephropathy[J].Nat Rev Nephrol,2016,12(3):147-156.
[8]戴晓玮,钟良军,朱涛.伴慢性牙周炎冠心病患者动脉粥样硬化斑块中牙龈卟啉单胞菌牙龈素基因片段检测[J].中华实用诊断与治疗杂志,2013,27(7):673-675.
[9]WALLER T,KESPER L,HIRSCHFELD J,et al.Porphyromonas gingivalis outer membrane vesicles induce selective tumor necrosis factor tolerance in a Toll-like receptor 4-and mTOR-dependent manner[J].Infect Immun,2016,84(4):1194-1204.
[10]OTENIO C C,FONSECA I,MARTINS M F,et al.Expression of IL-1β,IL-6,TNF-α,and iNOS in pregnant women with periodontal disease[J].Genet Mol Res,2012,11(4):4468-4478.
[11]TAN J,ZHOU L,XUE P,et al.Tumor necrosis factor-αattenuates the osteogenic differentiation capacity of periodontal ligament stem cells by activating PERK signaling[J].JPeriodontol,2016,87(8):159-171.
[12]CORTELA D C,DE SOUZA JUNIOR A L,VIRMOND M C,et al.Inflammatory mediators of leprosy reactional episodes and dental infections:a systematic review[J].Mediators Inflamm,2015:548540.
[13]BORAWSKI J,WILCZYNSKA-BORAWSKA M,STOKOWSKA W,et al.The periodontal status of pre-dialysis chronic kidney disease and maintenance dialysis patients[J].Nephrol Dial Transplant,2007,22(2):457-464.
[14]IOANNIDOU E,SWEDE H,DONGARI-BAGTZOGLOU A.Periodontitis predicts elevated C-reactive protein levels in chronic kidney disease[J].J Dent Res,2011,90(12):1411-1415.
[15]SCHMITT R,STAHL A L,OLIN A I,et al.The combined role of galactose-deficient IgA1and streptococcal IgA-binding M protein in inducing IL-6 and C3 secretion from human mesangial cells:implications for IgA nephropathy[J].JImmunol,2014,193(1):317-326.
[16]许志鹏,宋勇,孙燕.伴有牙周炎的IgA肾病患者牙周治疗前后血清TNF-α与IL-8变化分析[J].海南医学,2015,26(18):2681-2683.
[17]李静,李增录,桑晓红,等.慢性牙周炎与慢性肾衰竭动物模型中IL-1β的表达[J].中国中西医结合肾病杂志,2010,11(7):586-589.
[18]刘衍杰,李静,桑晓红,等.没食子提取物对IgAN大鼠尿液及肾组织IL-6表达的影响[J].中国中西医结合肾病杂志,2016,17(3):218-220.
[19]MAEKAWA T,ABE T,HAJISHENGALLIS E,et al.Genetic and intervention studies implicating complement C3as a major target for the treatment of periodontitis[J].J Immunol,2014,192(12):6020-6027.
[20]ABE T,HOSUR K B,HAJISHENGALLIS E,et al.Local complement-targeted intervention in periodontitis:proof-ofconcept using a C5a receptor(CD88)antagonist[J].JImmunol,2012,189(11):5442-5448.
[21]YOU Y K,HUANG X R,CHEN H Y,et al.C-reactive protein promotes diabetic kidney disease in db/db mice via the CD32b-Smad3-mTOR signaling pathway[J].Sci Rep,2016,6:26740.
[22]COPPO R,CAMILLA R,AMORE A,et al.Toll-like receptor4expression is increased in circulating mononudear cells of patients with immunoglobulin A nephropathy[J].Exp Irmnunol,2010,159(1):73-81.
[23]BORGNAKKE W S.Periodontitis may be associated with chronic kidney disease,but current evidence is insufficient[J].J Evid Base Dent Pract,2013,13(3):88-90.
[24]KSHIRSAGAR A V,GRUBBS V.Periodontal disease and CKD-associated morbidity:is there now enough evidence to move from observation to intervention?[J].Am J Kidney Dis,2015,66(2):181-183.
[25]曹娅丽,乔敏,徐志宏,等.IgA肾病患者合并慢性重度和侵袭性牙周炎的临床特点[J].中华医学杂志,2016,30(1):9-13.
[26]李静,张静,刘健,等.慢性牙周炎与IgA肾病复合动物模型的建立及相互关系[J].中华肾脏病杂志,2013,29(11):842-848.
[27]李团结,李静,刘健,等.大鼠CP与IgAN复合模型临床参数及病理改变的研究[J].口腔医学研究,2014,30(7):622-626.
[28]王丽娜,李静,刘健,等.大鼠慢性牙周炎与IgA肾病复合模型血清中MMP-3的表达及意义[J].口腔医学研究,2013,29(11):1034-1038.