HIV感染患者血清IL-2、IL-16水平和CD4细胞计数的相关性分析
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摘要
目的:探讨人类免疫缺陷病毒(HIV)感染患者血清白细胞介素-2(IL-2)、白细胞介素-16(IL-16)水平和CD4细胞计数的相关性。方法:选择2017年3月至2018年3月我院接诊的50例HIV感染患者作为观察组及同期于我院进行体检的健康人群40例作为对照组。检测和比较两组血清IL-2、IL-16与CD4细胞计数,并分析观察组血清IL-2、IL-16与CD4细胞计数的相关性。结果:观察组患者血清IL-2、IL-16水平及CD4细胞计数显著低于对照组,差异具有统计学意义(P<0.05);Pearson相关分析结果显示观察组患者血清IL-2、IL-16水平与CD4细胞计数呈显著正相关(r=0.514,r=0.499,P<0.05)。结论:HIV感染患者血清IL-2、IL-16水平显著下调,并与CD4细胞计数呈显著正相关,可在一定程度上反映HIV感染的严重度。
Objective: To study Analysis of the Correlation between serum il-2, il-16 levels and CD4 cell counts in hiv-infected patients. Methods: 50 patients with HIV infection admitted to our hospital from March 2017 to March 2018 were selected as the observation group and 40 healthy people who underwent physical examination in our hospital during the same period as the control group, the serum il-2, il-16 and CD4 cell counts in the two groups were detected and compared, and the correlation between serum il-2, il-16 and CD4 cell counts in the observation group was analyzed. Results: Serum il-2, il-16 levels and CD4 cell counts in the observation group were significantly lower than those in the control group, with statistically significant differences(P<0.05). Pearson correlation analysis showed that serum il-2 and il-16 levels in the observation group were significantly positively correlated with CD4 cell count(r=0.514,r=0.499, P<0.05). Conclusion: Serum il-2 and il-16 levels of hiv-infected patients were significantly down-regulated and positively correlated with CD4 cell count, which can reflect the severity of HIV infection to some extent.
Objective: To study Analysis of the Correlation between serum il-2, il-16 levels and CD4 cell counts in hiv-infected patients. Methods: 50 patients with HIV infection admitted to our hospital from March 2017 to March 2018 were selected as the observation group and 40 healthy people who underwent physical examination in our hospital during the same period as the control group, the serum il-2, il-16 and CD4 cell counts in the two groups were detected and compared, and the correlation between serum il-2, il-16 and CD4 cell counts in the observation group was analyzed. Results: Serum il-2, il-16 levels and CD4 cell counts in the observation group were significantly lower than those in the control group, with statistically significant differences(P<0.05). Pearson correlation analysis showed that serum il-2 and il-16 levels in the observation group were significantly positively correlated with CD4 cell count(r=0.514,r=0.499, P<0.05). Conclusion: Serum il-2 and il-16 levels of hiv-infected patients were significantly down-regulated and positively correlated with CD4 cell count, which can reflect the severity of HIV infection to some extent.
引文
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[2]De Rosa S C,Zaretsky M D,Dubs J G,et al.N-acetylcysteine replenishes glutathione in HIV infection[J].European Journal of Clinical Investigation,2015,30(10):915-929
[3]Aquaro S,CaliòR,Balzarini J,et al.Macrophages and HIV infection:therapeutical approaches toward this strategic virus reservoir[J].Antiviral Research,2016,55(2):209-225
[4]Marrazzo J M,Ramjee G,Richardson B A,et al.Tenofovir-based preexposure prophylaxis for HIV infection among African women[J]New England Journal of Medicine,2015,372(6):509-518
[5]Fletcher C V,Anderson P L,Kakuda T N,et al.Concentration-controlled compared with conventional antiretroviral therapy for HIV infection[J].Aids,2015,16(4):551-560
[6]Fitzgerald D W.HIV infection in Haiti:Natural history and disease progression[J].Aids,2017,14(16):2515-2521
[7]Keane F,Gompels M,Bendall R,et al.Hepatitis E virus coinfection in patients with HIV infection[J].Hiv Medicine,2015,13(1):83-88
[8]魨Nen N F,Overton E T,Seyfried W,et al.Aging and HIV Infection:A Comparison Between Older HIV-Infected Persons and the General Population[J].Hiv Clinical Trials,2015,11(2):100-109
[9]Enger C,Graham N,Peng Y,et al.Survival from early,intermediate,and late stages of HIV infection[J].Jama the Journal of the American Medical Association,2016,275(17):1329-1334
[10]Serraino D,Carrieri P,Pradier C,et al.Risk of invasive cervical cancer among women with,or at risk for,HIV infection[J].International Journal of Cancer,2015,82(3):334-337
[11]Müller F,Svardal A M,Nordoy I,et al.Virological and immunological effects of antioxidant treatment in patients with HIV infection[J].European Journal of Clinical Investigation,2015,30(10):905-914
[12]Dinh D M,Volpe G E,Duffalo C,et al.The Intestinal Microbiota,Microbial Translocation and Systemic Inflammation in Chronic HIVInfection[J].Journal of Infectious Diseases,2015,211(1):19-27
[13]Paisible A L,Chang C C,Soarmah K A,et al.HIV infection,cardiovascular disease risk factor profile,and risk for acute myocardial infarction[J].J Acquir Immune Defic Syndr,2015,68(2):209-216
[14]Shafiee H,Wang S,Inci F,et al.Emerging technologies for point-of-care management of HIV infection[J].Annual Review of Medicine,2015,66(1):387-405
[15]Velu V,Shetty R D,Larsson M,et al.Role of PD-1 co-inhibitory pathway in HIV infection and potential therapeutic options[J].Retrovirology,2015,12(1):1-17
[16]Josephson F.Drug-drug interactions in the treatment of HIV infection:focus on pharmacokinetic enhancement through CYP3A inhibition[J].Journal of Internal Medicine,2015,268(6):530-539
[17]Portegies P,Solod L,Cinque P,et al.Guidelines for the diagnosis and management of neurological complications of HIV infection[J].European Journal of Neurology the Official Journal of the European Federation of Neurological Societies,2015,11(5):297-304
[18]Helbling B,Von O J,Lauterburg B H.Decreased release of glutathione into the systemic circulation of patients with HIV infection[J].European Journal of Clinical Investigation,2015,26(1):38-44
[19]Mfinanga S,Chanda D,Kivuyo S L,et al.Cryptococcal meningitis screening and community-based early adherence support in people with advanced HIV infection starting antiretroviral therapy in Tanzania and Zambia:an open-label,randomised controlled trial[J].Lancet,2015,385(9983):2173-2182
[20]Ma S,Estes J D,Deleage C,et al.Gut epithelial barrier and systemic inflammation during chronic HIV infection[J].Aids,2015,29(1):43-51
[21]Almeida F A,Neves F F,Mora D J,et al.Paracoccidioidomycosis in Brazilian Patients with and without Human Immunodeficiency Virus Infection[J].American Journal of Tropical Medicine&Hygiene,2017,96(2):368-372
[22]Bloomfield G S,Leung C.Cardiac Disease Associated with Human Immunodeficiency Virus Infection[J].Cardiology Clinics,2017,35(1):59-70
[23]Asgari M M,Ray G T,Jr Q C,et al.Association of Multiple Primary Skin Cancers With Human Immunodeficiency Virus Infection,CD4Count,and Viral Load[J].Jama Dermatology,2017,153(9):892-896
[24]Skarlis C,Gontika M,Katsavos S,et al.Multiple Sclerosis and Subsequent Human Immunodeficiency Virus Infection:A Case with the Rare Comorbidity,Focus on Novel Treatment Issues and Review of the Literature[J].Vivo,2017,31(5):1041
[25]Lake J E,Popov M,Post W S,et al.Visceral fat is associated with brain structure independent of human immunodeficiency virus infection status[J].Journal of Neurovirology,2017,23(3):1-9
[26]Lin K Y,Chen G J,Lee Y L,et al.Hepatitis A virus infection and hepatitis A vaccination in human immunodeficiency virus-positive patients:A review[J].World Journal of Gastroenterology,2017,23(20):3589-3606
[27]Bryant A K,Moore D J,Burdo T H,et al.Plasma soluble CD163 is associated with postmortem brain pathology in human immunodeficiency virus infection[J].Aids,2017,31(7):973-979
[28]Sonderup M W,Wainwright H C.Human Immunodeficiency Virus Infection,Antiretroviral Therapy,and Liver Pathology[J].Gastroenterol Clin North Am,2017,46(2):327-343
[29]Gebremicael G,Amare Y,Challa F,et al.Lipid Profile in Tuberculosis Patients with and without Human Immunodeficiency Virus Infection[J].International Journal of Chronic Diseases,2017,2017(5):1-7
[30]Madhi S A,Cutland C L,Downs S,et al.Burden of Respiratory Syncytial Virus Infection in South African Human Immunodeficiency Virus(HIV)-Infected and HIV-Uninfected Pregnant and Postpartum Women:A Longitudinal Cohort Study[J].Clinical Infectious Diseases An Official Publication of the Infectious Diseases Society of America,2018,66(11):1658-1665
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