植物源性食品中抗生素残留分析方法研究进展
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摘要
为评估抗生素对人体暴露的健康风险,需建立针对植物样品中抗生素残留的快速筛查及确证检测方法。文章简要介绍了中国抗生素农药的登记情况及其限量标准、植物源性食品中抗生素的来源及在植物中的累积情况,重点对目前植物源性食品中抗生素残留前处理技术和检测技术进行详细的综述,并对该领域的工作进行了展望。
In order to assess the health risks of antibiotic exposure to humans,it is needed to establish the rapid screening and confirmation testing methods for antibiotic residues in plant samples.This paper briefly introduces the registration and limit standards of agricultural antibiotics in China,the origin and accumulation of antibiotics in plant-derived foods,especially the present pretreatment and detection techniques of antibiotic residues in plant-derived foods,and prospects the work in this field.
In order to assess the health risks of antibiotic exposure to humans,it is needed to establish the rapid screening and confirmation testing methods for antibiotic residues in plant samples.This paper briefly introduces the registration and limit standards of agricultural antibiotics in China,the origin and accumulation of antibiotics in plant-derived foods,especially the present pretreatment and detection techniques of antibiotic residues in plant-derived foods,and prospects the work in this field.
引文
[1]RIZZETTI T M,SOUZA M P D,PRESTES O D,et al.Optimization of sample preparation by central composite design for multi-class determination of veterinary drugs in bovine muscle,kidney and liver by ultra-high-performance liquid chromatographic-tandem mass spectrometry[J].Food Chemistry,2018,246:404-413.
[2]DELATOUR T,RACAULT L,BESSAIRE T,et al.Screening of veterinary drug residues in food by LC-MS/MS.Background and challenges[J].Food Additives&Contaminants Part A Chemistry Analysis Control Exposure&Risk Assessment,2018,35(4):632-645.
[3]李周敏,孙艳艳,姚开安,等.动物源性食品中抗生素残留检测前处理及其分析方法研究进展[J].药物分析杂志,2013(6):901-906.
[4]唐韵.微生物源抗生素农药简介[J].农化市场十日讯,2017(4):26-29.
[5]中华人民共和国国家卫生和计划生育委员会,中华人民共和国农业部,国家食品药品监督管理总局.GB 2763-2016食品安全国家标准食品中农药最大残留限量[S].北京:农业标准出版研究中心,2016.
[6]DAGHRIR R,DROGUI P.Tetracycline antibiotics in the environment:a review[J].Environmental Chemistry Letters,2013,11(3):209-227.
[7]HU Xian-gang,ZHOU Qi-xing,LUO Yi.Occurrence and source analysis of typical veterinary antibiotics in manure,soil,vegetables and groundwater from organic vegetable bases,northern China[J].Environmental Pollution,2010,158(9):2 992-2 998.
[8]ZHANG Yu-ping,SALLACH J B,HODGES L,et al.Effects of soil texture and drought stress on the uptake of antibiotics and the internalization of Salmonella,in lettuce following wastewater irrigation[J].Environmental Pollution,2016,208:523-531.
[9]PAN Min,CHU L M.Fate of antibiotics in soil and their uptake by edible crops[J].Science of the Total Environment,2017,599-600:500-512.
[10]PAN Min,CHU L M.Phytotoxicity of veterinary antibiotics to seed germination and root elongation of crops[J].Ecotoxicology&Environmental Safety,2016,126:228-237.
[11]MINDEN V,DELOY A,VOLKERT A M,et al.Antibiotics impact plant traits,even at small concentrations[J].Aob Plants,2017,9(2):1-9.
[12]SAAD M M.The risk of human exposure to antibiotic residues from food of both animal and plant origin[J].European Journal of Biomedical and Pharmaceutical Sciences,2016,3(5):12-15.
[13]KANG D H,GUPTA S,ROSEN C,et al.Antibiotic uptake by vegetable crops from manure-applied soils[J].Journal of Agricultural&Food Chemistry,2013,61(42):9 992-10 001.
[14]AHMED M B M,RAJAPAKSHA A U,LIM J E,et al.Distribution and accumulative pattern of tetracyclines and sulfonamides in edible vegetables of cucumber,tomato and lettuce[J].Journal of Agricultural&Food Chemistry,2015,63(2):398-405.
[15]吴小莲,莫测辉,李彦文,等.蔬菜中喹诺酮类抗生素污染探查与风险评价:以广州市超市蔬菜为例[J].环境科学,2011,32(6):1 703-1 709.
[16]金彩霞,司晓薇,王子英,等.养殖场周边土壤-蔬菜系统磺胺类药物残留及风险评价[J].环境科学,2016,37(4):1 562-1 567.
[17]XIE Xian-chuan,WANG Xia-rong,ZHAO Li.A fast,simple,and reliable high-performance liquid chromatography(HPLC)method for determining abamectin residues in vegetables and fruits[J].Food Analytical Methods,2011,4(2):203-211.
[18]WANG Tie-long,YIN Shao-yin,HU Ji-ye.Dissipation and residue determination of ningnanmycin in cucumber and soil by high performance liquid chromatography with ultraviolet detector[J].Bulletin of Environmental Contamination and Toxicology,2013,90(2):256-259.
[19]LIU Xue,ABD E A M,JI-YEON P,et al.Determination of spinetoram in leafy vegetable crops using liquid chromatography and confirmation via tandem mass spectrometry[J].Biomedical Chromatography Bmc,2011,25(10):1 099-1 106.
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[21]ALDEEK F,HAMMACK W,CROSSWHITE M R,et al.LC-MS/MS Validation of a Residue Analysis Method for Penicillin G and Its Metabolites in Commercial Orange Juice[J].Journal of AOAC International,2017,100(1):189-197.
[22]LIDA A,MOYANO E,GALCERAN M T.Simultaneous analysis of kasugamycin and streptomycin in vegetables by liquid chromatography-tandem mass spectrometry[J].Analytical Methods,2015,7(8):3 600-3 607.
[23]KOTTIAPPAN M,CHANDRAN S.Estimation of abamectin residues present in tea:high-performance liquid chromatography technique[J].Isrn Chromatography,2013,2013(5):1 958-1 969.
[24]HU Feng-yang,BIAN Kui,LIU Ya-hong,et al.Development of a modified QUick,Easy,CHeap,Effective,Rugged and Safe method for the determination of multiclass antimicrobials in vegetables by liquid chromatography tandem mass spectrometry[J].Journal of Chromatography A,2014,1 368:52-63.
[25]CHUANG Ya-hui,ZHANG Ying-jie,ZHANG Wei,et al.Comparison of accelerated solvent extraction and quick,easy,cheap,effective,rugged and safe method for extraction and determination of pharmaceuticals in vegetables[J].Journal of Chromatography A,2015,1 404:1-9.
[26]RAHMAN M M,ABD E A M,KIM S W,et al.A simple extraction method for the detection and quantification of polyoxin D,a nucleoside antibiotic,in butterbur using UP-LC-MS/MS[J].Food Chemistry,2017,221:683-688.
[27]段晓洁.喹诺酮类抗生素在蔬菜体内迁移和积累的研究[D].合肥:安徽农业大学,2012:17.
[28]吴小莲,包艳萍,向垒,等.固相萃取-高效液相色谱-串联质谱法同时测定蔬菜中8种磺胺类抗生素[J].环境化学,2013,32(6):1 038-1 044.
[29]PATRCIAPENIDO M,SUSANNE R,FELIXGUILLER-MOREYES R.Determination of oxytetracycline in tomatoes by HPLC using fluorescence detection[J].Food Chemistry,2008,109(1):212-218.
[30]李学德,鲜啟明,刘红玲,等.高效液相色谱-荧光检测法同时测定蔬菜中3种磺胺类药物残留[J].分析化学,2010,38(3):429-433.
[31]刘雪,余晟,韦彩云,等.固相萃取-高效液相法测定蔬菜中6种磺胺类药物[J].食品科学,2013,34(2):204-208.
[32]AZANU D,MORTEY C,DARKO G,et al.Uptake of antibiotics from irrigation water by plants[J].Chemosphere,2016,157:107-114.
[33]LIU Hong-cheng,ZHANG Ying,LIU Lian-liang,et al.Fast Separation ultra-performance liquid chromatography for determination of pre-column derivative abamectin and ivermectin residues in vegetable[J].Journal of Fluorescence,2011,21(2):825-829.
[34]WANG Chen-chen,LI Hong-e,WANG Ni,et al.Simultaneous analysis of kasugamycin and validamycin-A in fruits and vegetables using liquid chromatography-tandem mass spectrometry and consecutive solid-phase extraction[J].Analytical Methods,2016,9(4):634-642.
[35]CANZANI D,HSIEH K,STANDLAND M,et al.UHPLC-MS/MS method for the quantitation of penicillin Gand metabolites in citrus fruit using internal standards[J].Journal of Chromatography B,2017,1 044-1 045:87-94.
[36]YU Xiao-lu,LIU Hang,PU Cheng-jun,et al.Determination of multiple antibiotics in leafy vegetables using QuEChERS-UHPLC-MS/MS[J].Journal of Separation Science,2018,41(3):713-722.
[37]PIRSAHEB M,FATTAHI N,RAHIMI R,et al.Evaluation of abamectin,diazinon and chlorpyrifos pesticide residues in apple product of Mahabad region gardens:Iran in2014[J].Food Chemistry,2017,231:148-155.
[38]曹江平,邸宏伟,周继梅,等.分散液液微萃取技术的研究进展[J].分析测试学报,2016,35(7):913-921.
[39]ZHANG Ping,DING Jie,HOU Juan,et al.Dynamic microwave assisted extraction coupled with matrix solid phase dispersion for the determination of chlorfenapyr and abamectin in rice by LC-MS/MS[J].Microchemical Journal,2017,133:404-411.
[40]金芬,王静,魏闪闪,等.阿维菌素在黄瓜和土壤中的残留及其消解动态[J].中国农业科学,2014,47(18):3 684-3 690.
[41]HEMNDEZBORGES J,RAVELOPREZ L M,HERNNDEZSUREZ E M,et al.Analysis of abamectin residues in avocados by high-performance liquid chromatography with fluorescence detection[J].Journal of Chromatography A,2007,1165(1/2):52-57.
[42]VALENZUELA A I,POPA D S,REDONDO M J,et al.Comparison of various liquid chromatographic methods for the analysis of avermectin residues in citrus fruits[J].Journal of Chromatography A,2001,918(1):59-65.
[43]ZHA Yu-bing,YANG Chun-liang,WANG Ming-yue,et al.Multiresidue Determination of Avermectins in Plant-Derived Food by UPLC-MS/MS[J].Advanced Materials Research,2012,554-556:1 322-1 326.
[44]BENINCASA C,PERRI E,IANNOTTA N,et al.LC/ESI-MS/MS method for the identification and quantification of spinosad residues in olive oils[J].Food Chemistry,2011,125(3):1 116-1 120.
[45]DASENAKI M E,BLETSOU A A,HANAFI A H,et al.Liquid chromatography-tandem mass spectrometric methods for the determination of spinosad,thiacloprid and pyridalyl in spring onions and estimation of their pre-harvest interval values[J].Food Chemistry,2016,213:395-401.
[46]BOHM D A,STACHEL C S,GOWIK P.Confirmatory method for the determination of streptomycin in apples by LC-MS/MS[J].Analytica Chimica Acta,2010,672(1/2):103-106.
[47]CHEN Ben-jing,ZHANG Hong-yan,LIU Bao-xiang,et al.Determination of streptomycin residue in cucumber and Chinese cabbage by high-performance liquid chromatography with postcolumn derivatization and fluorometric detection[J].Journal of AOAC International,2012,95(2):523-527.
[48]段子恒.青霉素菌渣肥对土壤环境和西红柿生长的影响研究[D].哈尔滨:哈尔滨工业大学,2016:24-33.
[49]DANEZIS G P,ANAGNOSTOPOULOS C J,LIAPIS K,et al.Multi-residue analysis of pesticides,plant hormones,veterinary drugs and mycotoxins using HILIC chromatography-MS/MS in various food matrices[J].Analytica Chimica Acta,2016,942:121-138.
[50]LIU Na,DONG Feng-shou,Xu Jun,et al.Determination of Aminoglycoside Fungicide Validamycin A in Rice Plant by Quick,Easy,Cheap,Effective,Rugged,and Safe Approach Using Ultra High Performance Liquid Chromatography-Electrospray Ionization-Tandem Mass Spectrometry[J].Food Analytical Methods,2016,9(6):1 736-1 744.
[51]中华人民共和国国家卫生和计划生育委员会,中华人民共和国农业部,国家食品药品监督管理总局.GB 23200.19-2016食品安全国家标准水果和蔬菜中阿维菌素残留量的测定液相色谱法[S].北京:农业标准出版研究中心,2016.
[52]中华人民共和国国家卫生和计划生育委员会,中华人民共和国农业部,国家食品药品监督管理总局.GB 23200.20-2016食品安全国家标准食品中阿维菌素残留量的测定液相色谱-质谱/质谱法[S].北京:农业标准出版研究中心,2016.
[53]中华人民共和国国家卫生和计划生育委员会,中华人民共和国农业部,国家食品药品监督管理总局.GB 23200.74-2016食品安全国家标准食品中井冈霉素残留量的测定液相色谱-质谱/质谱法[S].北京:农业标准出版研究中心,2016.
[54]BASSIL R J,BASHOUR I I,SLEIMAN F T,et al.Antibiotic uptake by plants from manure-amended soils[J].Journal of Environmental Science and Health Part B:Pesticides Food Contaminants and Agricultural Wastes,2013,48(7):570-574
[55]ANGIONI A,PORCU L,PIRISI F.LC/DAD/ESI/MSMethod for the Determination of Imidacloprid,Thiacloprid,and Spinosad in Olives and Olive Oil after Field Treatment[J].Journal of Agricultural&Food Chemistry,2011,59(20):11 359-11 366.
[56]查玉兵,杨春亮,刘丽丽,等.反相高效液相色谱法测定龙眼中阿维菌素残留量[J].理化检验:化学分册,2008,45(5):36-38.
[57]LIU Yan-ping,SUN Hai-bin,WANG Si-wei.Dissipation and residue of spinosad in zucchini under field conditions[J].Bulletin of Environmental Contamination and Toxicology,2013,91(2):256-259.
[2]DELATOUR T,RACAULT L,BESSAIRE T,et al.Screening of veterinary drug residues in food by LC-MS/MS.Background and challenges[J].Food Additives&Contaminants Part A Chemistry Analysis Control Exposure&Risk Assessment,2018,35(4):632-645.
[3]李周敏,孙艳艳,姚开安,等.动物源性食品中抗生素残留检测前处理及其分析方法研究进展[J].药物分析杂志,2013(6):901-906.
[4]唐韵.微生物源抗生素农药简介[J].农化市场十日讯,2017(4):26-29.
[5]中华人民共和国国家卫生和计划生育委员会,中华人民共和国农业部,国家食品药品监督管理总局.GB 2763-2016食品安全国家标准食品中农药最大残留限量[S].北京:农业标准出版研究中心,2016.
[6]DAGHRIR R,DROGUI P.Tetracycline antibiotics in the environment:a review[J].Environmental Chemistry Letters,2013,11(3):209-227.
[7]HU Xian-gang,ZHOU Qi-xing,LUO Yi.Occurrence and source analysis of typical veterinary antibiotics in manure,soil,vegetables and groundwater from organic vegetable bases,northern China[J].Environmental Pollution,2010,158(9):2 992-2 998.
[8]ZHANG Yu-ping,SALLACH J B,HODGES L,et al.Effects of soil texture and drought stress on the uptake of antibiotics and the internalization of Salmonella,in lettuce following wastewater irrigation[J].Environmental Pollution,2016,208:523-531.
[9]PAN Min,CHU L M.Fate of antibiotics in soil and their uptake by edible crops[J].Science of the Total Environment,2017,599-600:500-512.
[10]PAN Min,CHU L M.Phytotoxicity of veterinary antibiotics to seed germination and root elongation of crops[J].Ecotoxicology&Environmental Safety,2016,126:228-237.
[11]MINDEN V,DELOY A,VOLKERT A M,et al.Antibiotics impact plant traits,even at small concentrations[J].Aob Plants,2017,9(2):1-9.
[12]SAAD M M.The risk of human exposure to antibiotic residues from food of both animal and plant origin[J].European Journal of Biomedical and Pharmaceutical Sciences,2016,3(5):12-15.
[13]KANG D H,GUPTA S,ROSEN C,et al.Antibiotic uptake by vegetable crops from manure-applied soils[J].Journal of Agricultural&Food Chemistry,2013,61(42):9 992-10 001.
[14]AHMED M B M,RAJAPAKSHA A U,LIM J E,et al.Distribution and accumulative pattern of tetracyclines and sulfonamides in edible vegetables of cucumber,tomato and lettuce[J].Journal of Agricultural&Food Chemistry,2015,63(2):398-405.
[15]吴小莲,莫测辉,李彦文,等.蔬菜中喹诺酮类抗生素污染探查与风险评价:以广州市超市蔬菜为例[J].环境科学,2011,32(6):1 703-1 709.
[16]金彩霞,司晓薇,王子英,等.养殖场周边土壤-蔬菜系统磺胺类药物残留及风险评价[J].环境科学,2016,37(4):1 562-1 567.
[17]XIE Xian-chuan,WANG Xia-rong,ZHAO Li.A fast,simple,and reliable high-performance liquid chromatography(HPLC)method for determining abamectin residues in vegetables and fruits[J].Food Analytical Methods,2011,4(2):203-211.
[18]WANG Tie-long,YIN Shao-yin,HU Ji-ye.Dissipation and residue determination of ningnanmycin in cucumber and soil by high performance liquid chromatography with ultraviolet detector[J].Bulletin of Environmental Contamination and Toxicology,2013,90(2):256-259.
[19]LIU Xue,ABD E A M,JI-YEON P,et al.Determination of spinetoram in leafy vegetable crops using liquid chromatography and confirmation via tandem mass spectrometry[J].Biomedical Chromatography Bmc,2011,25(10):1 099-1 106.
[20]WANG Chun-xian,ZHANG Zhi-gang,SHEN Yan,et al.Determination of validamycin A in agricultural food samples by solid-phase extraction combined with liquid chromatography-atmospheric pressure chemical ionisation-tandem mass spectrometry[J].Food Chemistry,2015,169:150-155.
[21]ALDEEK F,HAMMACK W,CROSSWHITE M R,et al.LC-MS/MS Validation of a Residue Analysis Method for Penicillin G and Its Metabolites in Commercial Orange Juice[J].Journal of AOAC International,2017,100(1):189-197.
[22]LIDA A,MOYANO E,GALCERAN M T.Simultaneous analysis of kasugamycin and streptomycin in vegetables by liquid chromatography-tandem mass spectrometry[J].Analytical Methods,2015,7(8):3 600-3 607.
[23]KOTTIAPPAN M,CHANDRAN S.Estimation of abamectin residues present in tea:high-performance liquid chromatography technique[J].Isrn Chromatography,2013,2013(5):1 958-1 969.
[24]HU Feng-yang,BIAN Kui,LIU Ya-hong,et al.Development of a modified QUick,Easy,CHeap,Effective,Rugged and Safe method for the determination of multiclass antimicrobials in vegetables by liquid chromatography tandem mass spectrometry[J].Journal of Chromatography A,2014,1 368:52-63.
[25]CHUANG Ya-hui,ZHANG Ying-jie,ZHANG Wei,et al.Comparison of accelerated solvent extraction and quick,easy,cheap,effective,rugged and safe method for extraction and determination of pharmaceuticals in vegetables[J].Journal of Chromatography A,2015,1 404:1-9.
[26]RAHMAN M M,ABD E A M,KIM S W,et al.A simple extraction method for the detection and quantification of polyoxin D,a nucleoside antibiotic,in butterbur using UP-LC-MS/MS[J].Food Chemistry,2017,221:683-688.
[27]段晓洁.喹诺酮类抗生素在蔬菜体内迁移和积累的研究[D].合肥:安徽农业大学,2012:17.
[28]吴小莲,包艳萍,向垒,等.固相萃取-高效液相色谱-串联质谱法同时测定蔬菜中8种磺胺类抗生素[J].环境化学,2013,32(6):1 038-1 044.
[29]PATRCIAPENIDO M,SUSANNE R,FELIXGUILLER-MOREYES R.Determination of oxytetracycline in tomatoes by HPLC using fluorescence detection[J].Food Chemistry,2008,109(1):212-218.
[30]李学德,鲜啟明,刘红玲,等.高效液相色谱-荧光检测法同时测定蔬菜中3种磺胺类药物残留[J].分析化学,2010,38(3):429-433.
[31]刘雪,余晟,韦彩云,等.固相萃取-高效液相法测定蔬菜中6种磺胺类药物[J].食品科学,2013,34(2):204-208.
[32]AZANU D,MORTEY C,DARKO G,et al.Uptake of antibiotics from irrigation water by plants[J].Chemosphere,2016,157:107-114.
[33]LIU Hong-cheng,ZHANG Ying,LIU Lian-liang,et al.Fast Separation ultra-performance liquid chromatography for determination of pre-column derivative abamectin and ivermectin residues in vegetable[J].Journal of Fluorescence,2011,21(2):825-829.
[34]WANG Chen-chen,LI Hong-e,WANG Ni,et al.Simultaneous analysis of kasugamycin and validamycin-A in fruits and vegetables using liquid chromatography-tandem mass spectrometry and consecutive solid-phase extraction[J].Analytical Methods,2016,9(4):634-642.
[35]CANZANI D,HSIEH K,STANDLAND M,et al.UHPLC-MS/MS method for the quantitation of penicillin Gand metabolites in citrus fruit using internal standards[J].Journal of Chromatography B,2017,1 044-1 045:87-94.
[36]YU Xiao-lu,LIU Hang,PU Cheng-jun,et al.Determination of multiple antibiotics in leafy vegetables using QuEChERS-UHPLC-MS/MS[J].Journal of Separation Science,2018,41(3):713-722.
[37]PIRSAHEB M,FATTAHI N,RAHIMI R,et al.Evaluation of abamectin,diazinon and chlorpyrifos pesticide residues in apple product of Mahabad region gardens:Iran in2014[J].Food Chemistry,2017,231:148-155.
[38]曹江平,邸宏伟,周继梅,等.分散液液微萃取技术的研究进展[J].分析测试学报,2016,35(7):913-921.
[39]ZHANG Ping,DING Jie,HOU Juan,et al.Dynamic microwave assisted extraction coupled with matrix solid phase dispersion for the determination of chlorfenapyr and abamectin in rice by LC-MS/MS[J].Microchemical Journal,2017,133:404-411.
[40]金芬,王静,魏闪闪,等.阿维菌素在黄瓜和土壤中的残留及其消解动态[J].中国农业科学,2014,47(18):3 684-3 690.
[41]HEMNDEZBORGES J,RAVELOPREZ L M,HERNNDEZSUREZ E M,et al.Analysis of abamectin residues in avocados by high-performance liquid chromatography with fluorescence detection[J].Journal of Chromatography A,2007,1165(1/2):52-57.
[42]VALENZUELA A I,POPA D S,REDONDO M J,et al.Comparison of various liquid chromatographic methods for the analysis of avermectin residues in citrus fruits[J].Journal of Chromatography A,2001,918(1):59-65.
[43]ZHA Yu-bing,YANG Chun-liang,WANG Ming-yue,et al.Multiresidue Determination of Avermectins in Plant-Derived Food by UPLC-MS/MS[J].Advanced Materials Research,2012,554-556:1 322-1 326.
[44]BENINCASA C,PERRI E,IANNOTTA N,et al.LC/ESI-MS/MS method for the identification and quantification of spinosad residues in olive oils[J].Food Chemistry,2011,125(3):1 116-1 120.
[45]DASENAKI M E,BLETSOU A A,HANAFI A H,et al.Liquid chromatography-tandem mass spectrometric methods for the determination of spinosad,thiacloprid and pyridalyl in spring onions and estimation of their pre-harvest interval values[J].Food Chemistry,2016,213:395-401.
[46]BOHM D A,STACHEL C S,GOWIK P.Confirmatory method for the determination of streptomycin in apples by LC-MS/MS[J].Analytica Chimica Acta,2010,672(1/2):103-106.
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