复方甘草酸苷治疗利福平所致药物性肝损伤的药学监测与临床评价
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摘要
目的:探讨采用复方甘草酸苷治疗由利福平引发的药物性肝损伤的临床效果与作用机制。方法:对南京市胸科医院急诊内科于2017年1月-2017年6月收治的60例由利福平引起的药物性肝损伤患者,采用复方甘草酸苷注射液治疗,在患者用药前和用药1天后对外周血中谷丙转氨酶、谷草转氨酶、总胆红素、碱性磷酸酶、γ-谷氨酰转移酶的含量进行检测,同时对患者的治疗周期和治疗效果进行评估。数据以SPSS 20.0软件进行统计学分析,当P<0.05时,则认为数据间的差异具有统计学意义。结果:经过治疗后,患者外周血谷丙转氨酶、谷草转氨酶、总胆红素、碱性磷酸酶、γ-谷氨酰转移酶的水平明显低于治疗前,且数据间差异具有统计学意义。结论:复方甘草酸苷注射液能够有效改善由利福平引发的药物性肝损伤患者的临床指标并加快患者康复。
Objective: To explore the clinical effects and mechanisms of compound glycyrrhizin in the treatment of drug-induced liver injury by Rifampicin. Methods: Sixty patients with drug-induced liver injury by Rifampicin from the department of emergency of Nanjing thoracic hospital from January 2017 to June 2017 were treated with compound glycyrrhizin injection. The levels of ALT, AST, Bilirubin, ALP, and γ-GT in peripheral blood were measured before treatment and one day after treatment. Moreover, the treatment cycle and treatment effects were evaluated. The data were statistically analyzed by SPSS 20.0 software and the differences were considered statistically significant when P < 0.05. Results: The levels of ALT, AST, Bilirubin, ALP, and γ-GT in peripheral blood after treatment were significantly lower than those before treatment, and the differences between the data were statistically significant. Conclusion: Compound glycyrrhizin injection can effectively improve the clinical indexes of patients with drug-induced liver injury by Rifampicin and accelerate the rehabilitation.
Objective: To explore the clinical effects and mechanisms of compound glycyrrhizin in the treatment of drug-induced liver injury by Rifampicin. Methods: Sixty patients with drug-induced liver injury by Rifampicin from the department of emergency of Nanjing thoracic hospital from January 2017 to June 2017 were treated with compound glycyrrhizin injection. The levels of ALT, AST, Bilirubin, ALP, and γ-GT in peripheral blood were measured before treatment and one day after treatment. Moreover, the treatment cycle and treatment effects were evaluated. The data were statistically analyzed by SPSS 20.0 software and the differences were considered statistically significant when P < 0.05. Results: The levels of ALT, AST, Bilirubin, ALP, and γ-GT in peripheral blood after treatment were significantly lower than those before treatment, and the differences between the data were statistically significant. Conclusion: Compound glycyrrhizin injection can effectively improve the clinical indexes of patients with drug-induced liver injury by Rifampicin and accelerate the rehabilitation.
引文
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[15]孙晓红,张良登,魏玮,等.甘草酸苷治疗非酒精性脂肪性肝炎的系统评价与Meta分析[J].世界中西医结合杂志,2015,(2):265-271.
[2]霍记平,李新刚,赵志刚.药物性肝损伤及其生物标志物的研究进展[J].药物不良反应杂志,2015,(6):444-448.
[3]江学富,汪凯,汪朝辉,等.198例药物性肝损伤临床分析[J].安徽医药,2014,(8):1553-1556.
[4]姚飞,汪燕燕.综合分析药物性肝损伤9355例[J].安徽医药,2011,15(10):1312-1314.
[5]赵先胜,翁伦华.还原型谷胱甘肽结合复方甘草酸苷治疗酒精性肝硬化的临床效果分析[J].健康研究,2017,37(4):403-405.
[6]陈建蓉,王霁,秦天强,等.复方甘草酸苷治疗慢性乙型肝炎的效果及安全性的meta分析[J].南方医科大学学报,2014,34(8):1224-1229.
[7]张悦,闫亮.熊去氧胆酸胶囊联合复方甘草酸苷片治疗脂肪性肝炎51例疗效观察[J].山西医药杂志,2015,(12):1420-1421.
[8]麻林梅.复方甘草酸苷治疗肺结核患者的化疗性肝损害疗效观察[J].山西医药杂志,2012,41(1):57-58.
[9]查月芳,曾文,胡建军,等.主要抗结核药物肝脏毒性的动物实验研究[J].中国防痨杂志,2006,28(3):174-177.
[10]贺露露.恩替卡韦联合复方甘草酸苷治疗代偿期乙肝肝硬化患者的效果分析[J].河南医学研究,2017,26(15):2765-2766.
[11]谢延,张胜男,曾显声,等.抗结核药物肝损伤220例临床分析[J].实用预防医学,2009,16(3):948-949.
[12]胡小霞.复方甘草酸苷注射液联合孟鲁司特钠治疗过敏性紫癜患者血清免疫指标及疗效观察[J].中国社区医师,2017,33(22):48-49.
[13]刘国利.复方甘草酸苷对抗结核药物所致药物性肝损害疗效观察[J].中华消化病与影像杂志:电子版,2012,2(1):48-49.
[14]Hirata A,Murakami Y,Shoji M,et al.Kinetics of Radical-scavenging Activity of Hesperetin and Hesperidin and Their Inhibitory Activity on COX-2 Expression[J].Anticancer Res,2005,25(5):3367-3374.
[15]孙晓红,张良登,魏玮,等.甘草酸苷治疗非酒精性脂肪性肝炎的系统评价与Meta分析[J].世界中西医结合杂志,2015,(2):265-271.
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