消炎散核冲剂联合加味金芙膏治疗儿童流行性腮腺炎热毒壅盛证的疗效研究
|
摘要
目的:观察消炎散核冲剂口服联合加味金芙膏外敷治疗儿童流行性腮腺炎热毒壅盛证的临床疗效。方法:选取本院儿科门诊90例确诊为流行性腮腺炎热毒壅盛证的患儿,采用中央随机系统通过智能手机软件随机分为3组,分别为治疗Ⅰ组、治疗Ⅱ组和对照组,每组均为30例,对照组选用蒲地蓝消炎口服液治疗,治疗Ⅰ组选用消炎散核冲剂口服联合加味金芙膏外敷,治疗Ⅱ组选用消炎散核冲剂口服,3组疗程均为5 d。比较3组患儿治疗前后主要症状(包括发热、腮部肿痛)、次要症状(包含面色、头痛、颌下肿块、咽红、口渴)、全部症状积分,并判定临床疗效。结果:对照组总有效率73. 33%,治疗Ⅰ组总有效率93. 33%,治疗Ⅱ组总有效率为70. 0%。与对照组及治疗Ⅱ组相比,治疗Ⅰ组的总有效率明显升高(P <0. 05),治疗Ⅱ组的总有效率与对照组相比无差别(P> 0. 05)。3组流行性腮腺炎患儿治疗后的主要、次要及全部症状积分均比治疗前减少(P <0. 05)。经治疗,治疗Ⅰ组主要、全部症状积分较对照组及治疗Ⅱ组下降(P <0. 05),治疗Ⅱ组主要、全部症状积分同对照组主要及全部积分相比差异无意义(P> 0. 05),治疗后3组患儿的次要症状积分经统计学分析差异无意义(P> 0. 05)。结论:消炎散核冲剂口服联合加味金芙膏外敷治疗儿童流行性腮腺炎热毒壅盛证疗效显著。
Objective: To observe the effectiveness of Xiaoyan Sanhe Decoction and Modified Jinfu Ointment in the treatment of toxic heat syndrome of mumps in children. Methods: By the method of central randomized,90 children with toxic heat syndrome of mumps were divided into treatment group Ⅰ,treatment group Ⅱand the control group. The control group was treated with Pudilan Xiaoyan Oral Liquid. The treatment groupⅠwas treated with Xiaoyan Sanhe Decoction and Modified Jinfu Ointment. The treatment group Ⅱwas treated with Xiaoyan Sanhe Decoction. Five days was a treatment course. And we compared the primary symptom integral,secondary and total integral before and after treatment. Results: The total effective rates of treatment group Ⅰ,treatment group Ⅱand the control group were respectively 93. 33%,70. 0% and 73. 33%. The total effective rate of treatment group Ⅰcompared with that of the other groups was statistically elevated( P < 0. 05). But the total effective rate had no difference between control group and treatment group Ⅱ( P > 0. 05). Before and after treatment there was statistically significant difference in the primary symptom integral,secondary and total integral( P < 0. 05). The treatment group Ⅰprimary symptom integral and total integral were statistically significant decreased after treatment compared with those of the other groups( P < 0. 05). There was no difference in the primary symptom integral or total integral after treatment between treatment group Ⅱand the control group( P > 0. 05). And there was no difference of the three groups' secondary symptom after treatment( P > 0. 05). Conclusion: Xiaoyan Sanhe Decoction and Modified Jinfu Ointment have excellent effectiveness in the treatment of toxic heat syndrome of mumps in children.
Objective: To observe the effectiveness of Xiaoyan Sanhe Decoction and Modified Jinfu Ointment in the treatment of toxic heat syndrome of mumps in children. Methods: By the method of central randomized,90 children with toxic heat syndrome of mumps were divided into treatment group Ⅰ,treatment group Ⅱand the control group. The control group was treated with Pudilan Xiaoyan Oral Liquid. The treatment groupⅠwas treated with Xiaoyan Sanhe Decoction and Modified Jinfu Ointment. The treatment group Ⅱwas treated with Xiaoyan Sanhe Decoction. Five days was a treatment course. And we compared the primary symptom integral,secondary and total integral before and after treatment. Results: The total effective rates of treatment group Ⅰ,treatment group Ⅱand the control group were respectively 93. 33%,70. 0% and 73. 33%. The total effective rate of treatment group Ⅰcompared with that of the other groups was statistically elevated( P < 0. 05). But the total effective rate had no difference between control group and treatment group Ⅱ( P > 0. 05). Before and after treatment there was statistically significant difference in the primary symptom integral,secondary and total integral( P < 0. 05). The treatment group Ⅰprimary symptom integral and total integral were statistically significant decreased after treatment compared with those of the other groups( P < 0. 05). There was no difference in the primary symptom integral or total integral after treatment between treatment group Ⅱand the control group( P > 0. 05). And there was no difference of the three groups' secondary symptom after treatment( P > 0. 05). Conclusion: Xiaoyan Sanhe Decoction and Modified Jinfu Ointment have excellent effectiveness in the treatment of toxic heat syndrome of mumps in children.
引文
[1]彭文伟.传染病学[M]. 6版.北京:人民卫生出版社,2004:82-84.
[2]汤健闻,柳智豪.我国流行性腮腺炎流行概况及其免疫预防[J].微生物学免疫学进展,2015,43(3):51-57.
[3]于静,刘元宝,汪志国,等. 2006-2015年江苏省流行性腮腺炎流行病学分析[J].现代预防医学,2017,44(6):961-964.
[4]流行性腮腺炎(流腮)[J].中国神经免疫学和神经病学杂志,2017,24(1):70.
[5]郑霄雁,黄春文,廖冬冬. 2010-2012年福州市流行性腮腺炎流行病学特征[J].职业与健康,2014,30(10):1355-1356.
[6]阮绵琦,朱甜甜.儿童流行性腮腺炎并发症98例临床分析[J].中国医药指南,2016,14(25):153.
[7]江载芳,申昆玲,沈颖.诸福棠实用儿科学[M]. 8版,北京:人民卫生出版社,2015:851-853.
[8]汪受传,虞坚尔.普通高等教育“十二五”国家级规划教材·中医儿科学[M]. 9版.北京:中国中医药出版社,2014:247-252.
[9]赵霞,秦艳虹,董盈妹,等.中医儿科临床诊疗指南·流行性腮腺炎(修订)[J].中医儿科杂志,2017,13(1):1-5.
[10]郑筱萸.中药新药临床研究指导原则(试行)[M].北京:中国医药科技出版社,2002:56-58.
[11]王雪峰,郑健.中西医结合儿科学[M]. 3版.北京:中国中医药出版社,2016:963-970.
[12]汪受传.中医儿科学[M].上海:上海科学技术出版社,2006:202-205.
[13]阳进.中西医结合治疗流行性腮腺炎临床疗效观察[J].四川中医,2016,34(9):153-155.
[14]王春娟.仙人掌、紫花地丁外敷治疗流行性腮腺炎143例[J].中国中医药科技,2015,22(3):323-324.
[15]王叶芳.消炎散核冲剂治疗小儿肠系膜淋巴结炎临床观察[J].新中医,2012,44(3):62-63.
[16]贡献宇.加味金芙膏治疗急性淋巴管炎经验[J].实用中西医结合临床,2012,12(3):78-79.
[17]吴桂华,孙通华,崔艳霞.穴位贴敷的临床实验研究概况[J].中国中医药现代远程教育,2010,8(12):265-267.
[18]沈敏敏,徐冬萍.金黄散外敷联合敏感抗生素治疗小儿早期急性化脓性腮腺炎34例[J].浙江中医杂志,2014,49(8):590.
[19]赵瑞瑞,周帅.穴位贴敷疗法的临床应用进展[J].国医论坛,2017,32(1):68-70.
[20]谢洋,余学庆.试述穴位贴敷的作用机理及其临床运用[J].中国医药指南,2008,24(6):320-322.
[21]刘羽,李英.如意金黄散合用矾冰液外敷治疗小儿流行性腮腺炎的临床护理[J].湖南中医药大学学报,2016,36(6):82-84.
[2]汤健闻,柳智豪.我国流行性腮腺炎流行概况及其免疫预防[J].微生物学免疫学进展,2015,43(3):51-57.
[3]于静,刘元宝,汪志国,等. 2006-2015年江苏省流行性腮腺炎流行病学分析[J].现代预防医学,2017,44(6):961-964.
[4]流行性腮腺炎(流腮)[J].中国神经免疫学和神经病学杂志,2017,24(1):70.
[5]郑霄雁,黄春文,廖冬冬. 2010-2012年福州市流行性腮腺炎流行病学特征[J].职业与健康,2014,30(10):1355-1356.
[6]阮绵琦,朱甜甜.儿童流行性腮腺炎并发症98例临床分析[J].中国医药指南,2016,14(25):153.
[7]江载芳,申昆玲,沈颖.诸福棠实用儿科学[M]. 8版,北京:人民卫生出版社,2015:851-853.
[8]汪受传,虞坚尔.普通高等教育“十二五”国家级规划教材·中医儿科学[M]. 9版.北京:中国中医药出版社,2014:247-252.
[9]赵霞,秦艳虹,董盈妹,等.中医儿科临床诊疗指南·流行性腮腺炎(修订)[J].中医儿科杂志,2017,13(1):1-5.
[10]郑筱萸.中药新药临床研究指导原则(试行)[M].北京:中国医药科技出版社,2002:56-58.
[11]王雪峰,郑健.中西医结合儿科学[M]. 3版.北京:中国中医药出版社,2016:963-970.
[12]汪受传.中医儿科学[M].上海:上海科学技术出版社,2006:202-205.
[13]阳进.中西医结合治疗流行性腮腺炎临床疗效观察[J].四川中医,2016,34(9):153-155.
[14]王春娟.仙人掌、紫花地丁外敷治疗流行性腮腺炎143例[J].中国中医药科技,2015,22(3):323-324.
[15]王叶芳.消炎散核冲剂治疗小儿肠系膜淋巴结炎临床观察[J].新中医,2012,44(3):62-63.
[16]贡献宇.加味金芙膏治疗急性淋巴管炎经验[J].实用中西医结合临床,2012,12(3):78-79.
[17]吴桂华,孙通华,崔艳霞.穴位贴敷的临床实验研究概况[J].中国中医药现代远程教育,2010,8(12):265-267.
[18]沈敏敏,徐冬萍.金黄散外敷联合敏感抗生素治疗小儿早期急性化脓性腮腺炎34例[J].浙江中医杂志,2014,49(8):590.
[19]赵瑞瑞,周帅.穴位贴敷疗法的临床应用进展[J].国医论坛,2017,32(1):68-70.
[20]谢洋,余学庆.试述穴位贴敷的作用机理及其临床运用[J].中国医药指南,2008,24(6):320-322.
[21]刘羽,李英.如意金黄散合用矾冰液外敷治疗小儿流行性腮腺炎的临床护理[J].湖南中医药大学学报,2016,36(6):82-84.