复方苦参注射液联合顺铂胸腔灌注治疗老年恶性胸腔积液的临床研究
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摘要
目的:观察纳入的老年恶性腔积液患者经复方苦参注射液联合顺铂胸腔灌注治疗的临床疗效分析。方法:选择2015年8月-2017年12月的恶性胸腔积液患者共40例,将40例患者随机分为对照组和观察组各20例,对照组采用复方苦参注射液单药胸腔灌注治疗。观察组采用复方苦参注射液联合顺铂胸腔灌注治疗。观察两组患者的临床疗效,以《中药新药临床研究指导原则》(2002版)制定中医证候疗效改善率、VEGF含量。结果:观察组的治疗总有效率为80.00%,高于对照组的50.00%(P <0.05);观察组的治疗临床症状改善率为95.00%,高于对照组的70.00%(P <0.05),对比差异具有统计学意义。结论:复方苦参注射液联合顺铂胸腔灌注治疗老年恶性胸腔积液的临床疗效较高,能有效改善中医临床症状及体征。
Objective: To observe clinical efficacy of the Fufang Kushen injection( 复方苦参注射液) plus cisplatinum intrapleural infusion on geriatric malignant pleural effusion. Methods: 40 cases were divided into two groups, 20 cases in each. The control group was given the Fufang Kushen injection; and the observation group was given cisplatinum intrapleural infusion more. Results: The total efficiency was 80.00% in the observation group, higher than 50.00% in the control group, P<0.05. The clinical symptom improvement rate was 95.00% in the observation group, higher than 70.00% in the control group(P<0.05). Conclusion: The Fufang Kushen injection plus cisplatinum intrapleural infusion on geriatric malignant pleural effusion show a good effect.
Objective: To observe clinical efficacy of the Fufang Kushen injection( 复方苦参注射液) plus cisplatinum intrapleural infusion on geriatric malignant pleural effusion. Methods: 40 cases were divided into two groups, 20 cases in each. The control group was given the Fufang Kushen injection; and the observation group was given cisplatinum intrapleural infusion more. Results: The total efficiency was 80.00% in the observation group, higher than 50.00% in the control group, P<0.05. The clinical symptom improvement rate was 95.00% in the observation group, higher than 70.00% in the control group(P<0.05). Conclusion: The Fufang Kushen injection plus cisplatinum intrapleural infusion on geriatric malignant pleural effusion show a good effect.
引文
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[5]刘安家,张跃强,曾祥学,等.热疗联合艾迪注射液及顺铂胸腔灌注治疗恶性胸腔积液的疗效观察[J].中医临床研究,2017,9(7):90-91.
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[8]夏冬琴,王维.中药贴敷法在恶性胸腔积液治疗中的应用研究[J].实用中医药杂志,2017,33(1):107-109.
[9]陈永福,罗业春,覃祖光,等.复方苦参注射液联合顺铂治疗老年恶性胸腔积液的疗效观察[J].中西医结合研究,2014,6(4):196-197,199.
[2]石磊,杨卫兵,柏玉举,等.顺铂联合重组人血管内皮抑素对老年恶性胸腔积液血管内皮生长因子?血基质金属蛋白酶-9表达及生活质量的影响[J].中国老年学杂志,2016,36(17):4230-4232.
[3]马金丽,艾兰·塔拉干,吴涛,等.复方苦参注射液联合化疗治疗晚期结直肠癌效果的系统评价[J].广州中医药大学学报,2016,33(3):425-431.
[4]Viriolas N,Provenci M,Requart N,et al.Single nucleotide polymorphisms in MDR1 gen correlates with outcome in advanced nonsmall-cell lung cancer patients treated with cisplatin plus vinorelbine[J].Lung Cancer,2011,71(2):191-198.
[5]刘安家,张跃强,曾祥学,等.热疗联合艾迪注射液及顺铂胸腔灌注治疗恶性胸腔积液的疗效观察[J].中医临床研究,2017,9(7):90-91.
[6]王官成.VEGF在肿瘤血管及淋巴管生成中的研究[J].中国现代普通外科进展,2013,16(3):240-243.
[7]濮忠建,黄开红,张宝良.张宝良治疗恶性胸腔积液经验[J].光明中医,2016,31(20):2932-2934.
[8]夏冬琴,王维.中药贴敷法在恶性胸腔积液治疗中的应用研究[J].实用中医药杂志,2017,33(1):107-109.
[9]陈永福,罗业春,覃祖光,等.复方苦参注射液联合顺铂治疗老年恶性胸腔积液的疗效观察[J].中西医结合研究,2014,6(4):196-197,199.