金铁锁根中2个新的麦芽酚苷类化合物
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摘要
目的研究金铁锁Psammosilene tunicoides根的化学成分。方法经硅胶、Sephadex LH-20凝胶、ODS反相硅胶等柱色谱方法进行分离,并运用NMR、HR-ESI-MS等波谱学方法进行化合物的结构鉴定。结果从金铁锁根80%乙醇水提取物中分离得到2个麦芽酚苷类化合物,分别鉴定为麦芽酚-3-O-[6-O-(4-O-α-L-吡喃鼠李糖基)-Z-p-香豆酰基]-β-D-吡喃葡萄糖苷(1)和麦芽酚-3-O-[6-O-(4-O-α-L-吡喃鼠李糖基)-E-p-香豆酰基]-β-D-吡喃葡萄糖苷(2)。结论化合物1和2为新的麦芽酚苷类化合物,分别命名为金铁锁酚苷A和B。
Objective To investigate the chemical constituents from the roots of Psammosilene tunicoides. Methods Chemical constituents were separated by column chromatography over silica gel, Sephadex LH-20, and reverse-phase silica gel(ODS), and chemical structures were determined by analysis of HR-ESI-MS, 1 D, and 2 D NMR spectroscopic data. Results Two new maltol glycosides were isolated from the 80% aq. ethanol extract from the roots of P. tunicoides, and their structures were determined as maltol-3-O-[6-O-(4-O-α-L-rhamnopyranosyl)-Z-p-coumaroyl]-β-D-glucopyranoside(1) and maltol-3-O-[6-O-(4-O-α-Lrhamnopyranosyl)-E-p-coumaroyl]-β-D-glucopyranoside(2). Conclusion Compounds 1 and 2 are identified as new maltol glycosides, and named as tunicosides A and B, respectively.
Objective To investigate the chemical constituents from the roots of Psammosilene tunicoides. Methods Chemical constituents were separated by column chromatography over silica gel, Sephadex LH-20, and reverse-phase silica gel(ODS), and chemical structures were determined by analysis of HR-ESI-MS, 1 D, and 2 D NMR spectroscopic data. Results Two new maltol glycosides were isolated from the 80% aq. ethanol extract from the roots of P. tunicoides, and their structures were determined as maltol-3-O-[6-O-(4-O-α-L-rhamnopyranosyl)-Z-p-coumaroyl]-β-D-glucopyranoside(1) and maltol-3-O-[6-O-(4-O-α-Lrhamnopyranosyl)-E-p-coumaroyl]-β-D-glucopyranoside(2). Conclusion Compounds 1 and 2 are identified as new maltol glycosides, and named as tunicosides A and B, respectively.
引文
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[5]丁中涛,保志娟,杨雪琼,等.金铁锁根中的3个环二肽[J].中国中药杂志,2003,28(4):337-339.
[6]黄建华,肖建青,刘锡葵.中药金铁锁中一个新的环七肽[J].中国实验方剂学杂志,2013,19(22):120-123.
[7]许建阳,王发强,郑维发,等.金铁锁水煎浸膏对实验性类风湿关节痛镇痛作用的研究[J].武警医学,2003,14(10):589-591.
[8]王学勇,张元,许建阳,等.金铁锁总皂苷抗类风湿性关节炎作用及其作用机制研究[J].中国中药杂志,2006,31(5):419-421.
[9]Tian J M,Shen Y H,Yang X W,et al.Tunicyclin A,the first plant tricyclic ring cycloheptapeptide from Psammosilene tunicoides[J].Org Lett,2009,11(5):1131-1133.
[10]Tian J M,Shen Y H,Yang X W,et al.Antifungal cyclic peptides from Psammosilene tunicoides[J].J Nat Prod,2010,73(12):1987-1992.
[11]Zhang J G,Cao W J,Tian J M,et al.Evaluation of novel saponins from Psammosilene tunicoides and their analogs as immunomodulators[J].Int Immunopharmacol,2012,14(1):21-26.
[12]Tian J M,Shen Y H,Li H L,et al.Carboline alkaloids from Psammosilene tunicoides and their cytotoxic activities[J].Planta Med,2012,78(6):625-629.
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