解毒化瘀方肝豆灵片治疗肝豆状核变性的临床疗效观察
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摘要
目的:观察解毒化瘀方肝豆灵片治疗肝豆状核变性(HLD)患者肝纤维化的临床疗效。方法:采用随机对照法将患者分两组,治疗组用西药加肝豆灵片,对照组单用西药,疗程为6个月,分别观察治疗前、后中医临床证候积分,肝纤4项指标,肝功能,门静脉宽度、脾脏厚度等变化。结果:治疗6个月后治疗组较对照组同期中医证候积分,肝纤4项,肝功能,门静脉宽度、脾脏厚度均有改善(P<0.05)。结论:解毒化瘀方肝豆灵片能够改善HLD患者中医证候积分、肝纤4项、肝功能指标,并降低门脉宽度、减少脾脏长度和厚度。
Objective: To observe the clinical effect of jiedu huayu formula Gandouling Tablets on hepatic fibrosis in patients with hepatolenticular degeneration(HLD). Methods: The patients were divided into 2 groups by randomized control method, the treatment group was treated with western medicine plus Gandouling Tablets, the control group was treated with western medicine alone for 6 months. The changes of clinical symptom score of TCM, four results of liver fiber, liver function, the width of portal vein and spleen thickness were observed before and after the treatment. Results: After 6 months of treatment, the TCM symptom score, four results of liver fiber, liver function, portal vein width and spleen thickness in the treatment group were improved compared with the control group, the difference was statistically significant(P<0.05). Conclusion: Gandouling Tablets can improve the TCM symptom score, four results of liver fiber, liver function index, and reduce portal vein width and spleen length and thickness of HLD patients.
Objective: To observe the clinical effect of jiedu huayu formula Gandouling Tablets on hepatic fibrosis in patients with hepatolenticular degeneration(HLD). Methods: The patients were divided into 2 groups by randomized control method, the treatment group was treated with western medicine plus Gandouling Tablets, the control group was treated with western medicine alone for 6 months. The changes of clinical symptom score of TCM, four results of liver fiber, liver function, the width of portal vein and spleen thickness were observed before and after the treatment. Results: After 6 months of treatment, the TCM symptom score, four results of liver fiber, liver function, portal vein width and spleen thickness in the treatment group were improved compared with the control group, the difference was statistically significant(P<0.05). Conclusion: Gandouling Tablets can improve the TCM symptom score, four results of liver fiber, liver function index, and reduce portal vein width and spleen length and thickness of HLD patients.
引文
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[5]邓超文,龚正华,胡国信.《2016年亚太肝病学会共识指南:肝纤维化的侵入性和非侵入性评估》摘译.临床肝胆病杂志,2017,33(3):413-416
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[13]李金慈,陆兔林,毛春芹,等.莪术醋制前后抗复合因素致大鼠肝纤维化作用的比较研究.中草药,2013,44(19):2710-2716
[14]何科,梁韬.莪术多糖对猪血清所致肝纤维化大鼠的保护作用.中药药理与临床,2014,30(1):64-66
[15]欧意桃,杨桂智,兰天,等.黄连素对小鼠肝纤维化的影响.安徽中医药大学学报,2017,36(2):51-55
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[18]Ashraf K,Mujeeb M,Ahmad A,et al.Validated HPTLC analysis method for quantification of variability in content of curcumin in Curcuma longa L(turmeric)collected from different geographical region of India.Asian Pac J Trop Biomed,2012,2(2):584-588
[19]何丹丹,徐梦丹,曾白林,等.藏药印度獐牙菜抗四氯化碳诱导的大鼠肝纤维化的作用.中华中医药杂志,2017,32(10):4680-4683
[20]杨欣,李清林,陈卓辉,等.疏肝健脾活血方对肝纤维化过程中大鼠TGF-β1/Smad信号通路的影响.中华中医药杂志,2017,32(4):1694-1698
[2]Tai C S,Wu J F,Chen H L,et al.Modality of treatment and potential outcome of Wilson disease in Taiwan:A population-based longitudinal study.J Formos Med Assoc,2017,12(5):1-6
[3]张娟,鲍远程,谢道俊,等.肝豆灵对铜负荷大鼠肝纤维化血清代谢组学的影响.中医杂志,2014,55(3):232-237
[4]张影,孙万里.2012欧洲肝脏研究会肝豆状核变性(Wilson病)的诊治指南.中华临床医师杂志(电子版),2012,6(19):6011-6012
[5]邓超文,龚正华,胡国信.《2016年亚太肝病学会共识指南:肝纤维化的侵入性和非侵入性评估》摘译.临床肝胆病杂志,2017,33(3):413-416
[6]Aggarwal A,Bhatt M.Update on Wilson disease.Int Rev Neurobiol,2013,110(4):313-348
[7]Scheiber I F,Br?ha R,Du?ek P.Pathogenesis of Wilson disease.Handb Clin Neurol,2017,142(6):43-55
[8]薛本春,杨任民,胡纪源,等.肝豆汤Ⅳ号联合短期驱铜治疗对肝豆状核变性患者肝纤维化血清学指标的影响.中国中西医结合杂,2017,27(9):785-788
[9]汪瀚,杨文明,鲍远程.从铜毒论治肝豆状核变性初探.安徽中医药大学学报,2009,28(5):4-6
[10]杨文明,韩辉,鲍远程,等.中医对肝豆状核变性病因病机及辨证论治的探索.北京中医药大学学报(中医临床版),2012,19(4):6-9
[11]彭汝琴,王绍展,王媛媛,等.丹参素通过MEK/ERK信号通路抑制肝纤维化.中南药学,2017,15(5):580-586
[12]陈从显,徐爱钰,许勇,等.鸡血藤总黄酮对小鼠急性肝损伤的保护作用.滨州医学院学报,2012,35(3):189-191
[13]李金慈,陆兔林,毛春芹,等.莪术醋制前后抗复合因素致大鼠肝纤维化作用的比较研究.中草药,2013,44(19):2710-2716
[14]何科,梁韬.莪术多糖对猪血清所致肝纤维化大鼠的保护作用.中药药理与临床,2014,30(1):64-66
[15]欧意桃,杨桂智,兰天,等.黄连素对小鼠肝纤维化的影响.安徽中医药大学学报,2017,36(2):51-55
[16]Dong M X,Jia Y,Zhang Y B,et al.Emodin protects rat liver from CCl4-induced fibrogenesis via inhibition of hepatic stellate cells activation.World J Gastroenterol,2009,15(38):4753-4762
[17]王晓丽,张英博,李雪岩,等.大黄素对大鼠肝纤维化的影响及机理研究.中药药理与临床,2013,29(4):56-58
[18]Ashraf K,Mujeeb M,Ahmad A,et al.Validated HPTLC analysis method for quantification of variability in content of curcumin in Curcuma longa L(turmeric)collected from different geographical region of India.Asian Pac J Trop Biomed,2012,2(2):584-588
[19]何丹丹,徐梦丹,曾白林,等.藏药印度獐牙菜抗四氯化碳诱导的大鼠肝纤维化的作用.中华中医药杂志,2017,32(10):4680-4683
[20]杨欣,李清林,陈卓辉,等.疏肝健脾活血方对肝纤维化过程中大鼠TGF-β1/Smad信号通路的影响.中华中医药杂志,2017,32(4):1694-1698