血小板抗体检测在经产妇及多次妊娠产妇中的临床研究

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英文篇名：Clinical study of platelet antibody in second and multiple pregnancies 作者：赵枫 ; 张媛媛 ; 刘科益 ; 李美红 ; 洪莺 ; 张珍丹 英文作者：ZHAO Feng;ZHANG Yuan-yuan;LIU Ke-yi;LI Mei-hong;HONG Ying;ZHANG Zhen-dan;The Affiliated Hospital of Medical College of Ningbo University; 关键词：初产妇 ; 经产妇 ; 多次妊娠 ; 血小板抗体 ; 血小板减少 英文关键词：First-born women;;Maternity women;;Multiple pregnancy;;Platelet antibody;;Thrombocytopenia 中文刊名：ZWJZ 英文刊名：Chinese Journal of Health Laboratory Technology 机构：宁波大学医学院附属医院; 出版日期：2019-04-10 出版单位：中国卫生检验杂志 年：2019 期：v.29 基金：宁波大学校基金(XYY16050) 语种：中文; 页：ZWJZ201907015 页数：2 CN：07 ISSN：41-1192/R 分类号：47-48

摘要

目的研究经产妇抗血小板抗体发生阳性率,探讨妊娠与血小板(PLT)抗体的关系。方法对2 367例妊娠36周～41周初产妇及1 594例妊娠36周～41周经产妇进行PLT抗体筛查。结果初产妇PLT抗体阳性83例,阳性率为3.5%;经产妇PLT抗体阳性172例,阳性率为10.8%,经产妇抗体阳性率明显高于初产妇,组间差异有统计学意义(χ~2=83.903,P=0.000)。经产妇随着妊娠次数增多PLT抗体阳性率随妊娠次数增加而升高,差异有统计学意义(χ~2=4.467,P=0.035)。结论经产妇PLT抗体阳性率明显升高,其中多次妊娠阳性率显著升高。对经产妇进行PLT抗体筛查,阳性孕妇术前配合性血小板准备,大大降低血小板输注无效、输血不良反应以及新生儿同种免疫性血小板减少症都具有重要意义。
        Objective To study the positive rate of platelet antibody in second and multiple pregnancies, and the relation between platelet antibody and pregnancy. Methods PLT antibody was detected in 2 367 primipara with pregnancy of 36-41 weeks and 1 594 multipara with pregnancy of 36-41 weeks. Results A total of 83 cases were positive for PLT antibody in primipara, and the positive rate was 3.5%. 172 cases were positive in multipara, and the positive rate of PLT antibody was 10.8%. The positive rate of multipara was significantly higher than that of primipara, with the difference between groups statistically significant(χ~2=83.903, P=0.000). The positive rate of PLT antibodies increased with the number of pregnancies, and the difference was statistically significant(χ~2=4.467, P=0.035). Conclusion The positive rate of PLT antibody in women with two children increased and the positive rate of multiple pregnancies increased significantly. Preoperative platelet preparation can greatly reduce the ineffective platelet transfusion and adverse reactions of transfusion in positive pregnant women, which is of great significance for neonatal alloimmune thrombocytopenia.

引文

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