磷酸肌酸钠治疗冠心病并发心力衰竭的效果分析
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摘要
目的:探讨用磷酸肌酸钠治疗冠心病并发心力衰竭的效果。方法:将近年来贵阳市第三人民医院收治的50例冠心病并发心力衰竭患者分为观察组和对照组。对两组患者进行常规治疗,在此基础上为观察组患者加用磷酸肌酸钠进行治疗,然后观察其临床疗效。结果:治疗前,两组患者的收缩压、心率、6分钟步行试验的距离、脑钠肽(BNP)的水平及心室射血分数相比,P>0.05。治疗6周后,与对照组患者相比,观察组患者6分钟步行试验的距离较长,其BNP的水平较低,其心室射血分数较高,P <0.05;两组患者的收缩压和心率相比,P>0.05。结论:用磷酸肌酸钠治疗冠心病并发心力衰竭的效果较好,可改善其心肌代谢的情况。
objective: to investigate the effect of creatine phosphate sodium in the treatment of coronary heart disease complicated with heart failure. Methods: 50 cases of coronary heart disease complicated with heart failure admitted by the third people's hospital of guiyang in recent years were divided into observation group and control group. Patients in the two groups were given routine treatment. On this basis, patients in the observation group were treated with creatine phosphate sodium,and its clinical efficacy was observed. Results: before treatment, systolic blood pressure, heart rate, 6-minute walking distance, brain natriuretic peptide(BNP) level and ventricular ejection fraction were compared between the two groups(P > 0.05). After 6 weeks of treatment, compared with the control group, the observation group had a longer distance of 6-minute walking test, a lower level of BNP, and a higher ventricular ejection fraction(P < 0.05). Systolic blood pressure and heart rate were P > 0.05 in both groups. Conclusion: creatine phosphate is effective in treating coronary heart disease complicated with heart failure and can improve myocardial metabolism.
objective: to investigate the effect of creatine phosphate sodium in the treatment of coronary heart disease complicated with heart failure. Methods: 50 cases of coronary heart disease complicated with heart failure admitted by the third people's hospital of guiyang in recent years were divided into observation group and control group. Patients in the two groups were given routine treatment. On this basis, patients in the observation group were treated with creatine phosphate sodium,and its clinical efficacy was observed. Results: before treatment, systolic blood pressure, heart rate, 6-minute walking distance, brain natriuretic peptide(BNP) level and ventricular ejection fraction were compared between the two groups(P > 0.05). After 6 weeks of treatment, compared with the control group, the observation group had a longer distance of 6-minute walking test, a lower level of BNP, and a higher ventricular ejection fraction(P < 0.05). Systolic blood pressure and heart rate were P > 0.05 in both groups. Conclusion: creatine phosphate is effective in treating coronary heart disease complicated with heart failure and can improve myocardial metabolism.
引文
[1]中华医学会心血管病学分会,中国康复医学会心血管病专业委员会,中国老年学学会心脑血管病专业委员会.冠心病康复与二级预防中国专家共识[J].中华心血管病杂志,2013,41(4):267-275.
[2]中国药师协会,冠心病合理用药指南[J].中国医学前沿杂志,2016,8(6):19-108.
[3]Kristensen SD,Knuuti J,Saraste A,et al.2014 ESC/ESAGuidelines non-cardiac surgery:cardiovascular assessment and management:The Joint Task Force on noncardiac surgery:cardiovascular assessment and management of the European Society of Cardiology(ESC)and the European Society of Anaesthesiology(ESA)[J].Eur Heart J,2014,35(35):2383-2431.
[4]侯立向.一种心肌保护剂:磷酸肌酸[J].生物化学与生物物理进展,2003,30(2):324.
[5]GABR R E,EL-SHARKAWY A M,BOTTOMLEY P A,et al.Highenergy phosphate transfer in human muscle:diffusion of phosphocreatine[J].Am J Physiol Cell Physiol,2011,301(1):234-241.
[6]鲜文.磷酸肌酸钠辅助治疗高血压并发急性左心衰竭患者的临床研究[J].中国药师,2018,21(6):1048-1050,1060.
[7]WYSS M,KADDURAH-DAOUK R.Creatine and creatinine metabolism[J].Physiol Rev,2000,80(3):1107-1212.
[8]王艳.真武汤加味联合西药对慢性充血性心力衰竭患者血浆脑钠肽及6 min步行实验的影响[J].中国医药指南,2017,15(28):180-181.
[9]郭彤,王浩彦,徐秋芬,等.慢性阻塞性肺疾病患者6分钟步行实验与最大摄氧量关系研究[J].中国临床医生杂志,2015,43(1):37-39.
[10]郭金瑞,周红梅.参芪配方颗粒对气虚血瘀型心力衰竭伴冠心病患者6 min步行实验结果的影响[J].北京中医药,2014,33(6):416-418.
[11]韩国柱,唐泽耀.外源性磷酸肌酸心肌保护多靶作用机制的研究进展[J].医药导报,2018,37(2):165-171.
[12]章樱,陈国庆,张勤.磷酸肌酸钠对新生儿缺氧缺血性脑病氧化应激的影响及心肌损伤的保护作用[J].中华全科医学,2016,14(5):786-789.
[13]STRUMIA E,PELLICIA F,D’AMBROSIO G.Creatine phosphate:pharmacological and clinical perspectives[J].Adv Ther,2012,29(2):99-123.
[14]张会珍,邢艳秋,肖冬,等.磷酸肌酸联合缺血后适应对大鼠心肌缺血/再灌注损伤的保护作用[J].中国药理学通报,2012,28(11):1611-1614.
[15]邓小强,陈珂,姜徽,等.磷酸肌酸钠预先给药对2型糖尿病患者心肌缺血-再灌注损伤的影响[J].临床麻醉学杂志,2015,31(1):9-11.
[16]邹玲莉,李秋莎,等.离子对反相高效液相色谱法同时测定大鼠血浆和红细胞中外源性磷酸肌酸及其代谢产物和相关三磷酸腺苷[J].分析化学,2011,39(1):45-50.
[17]张燕,王文生,廉静,等.参附注射液联合磷酸肌酸钠治疗扩张型心肌病心功能不全效果[J].精准医学杂志,2018,33(3):256-258,262.
[18]石佳,袁素,薛庆华,等.冠心病患者围术期应用磷酸肌酸的心肌保护作用研究[J].中国分子心脏病学杂志,2010,10(1):44-47.
[2]中国药师协会,冠心病合理用药指南[J].中国医学前沿杂志,2016,8(6):19-108.
[3]Kristensen SD,Knuuti J,Saraste A,et al.2014 ESC/ESAGuidelines non-cardiac surgery:cardiovascular assessment and management:The Joint Task Force on noncardiac surgery:cardiovascular assessment and management of the European Society of Cardiology(ESC)and the European Society of Anaesthesiology(ESA)[J].Eur Heart J,2014,35(35):2383-2431.
[4]侯立向.一种心肌保护剂:磷酸肌酸[J].生物化学与生物物理进展,2003,30(2):324.
[5]GABR R E,EL-SHARKAWY A M,BOTTOMLEY P A,et al.Highenergy phosphate transfer in human muscle:diffusion of phosphocreatine[J].Am J Physiol Cell Physiol,2011,301(1):234-241.
[6]鲜文.磷酸肌酸钠辅助治疗高血压并发急性左心衰竭患者的临床研究[J].中国药师,2018,21(6):1048-1050,1060.
[7]WYSS M,KADDURAH-DAOUK R.Creatine and creatinine metabolism[J].Physiol Rev,2000,80(3):1107-1212.
[8]王艳.真武汤加味联合西药对慢性充血性心力衰竭患者血浆脑钠肽及6 min步行实验的影响[J].中国医药指南,2017,15(28):180-181.
[9]郭彤,王浩彦,徐秋芬,等.慢性阻塞性肺疾病患者6分钟步行实验与最大摄氧量关系研究[J].中国临床医生杂志,2015,43(1):37-39.
[10]郭金瑞,周红梅.参芪配方颗粒对气虚血瘀型心力衰竭伴冠心病患者6 min步行实验结果的影响[J].北京中医药,2014,33(6):416-418.
[11]韩国柱,唐泽耀.外源性磷酸肌酸心肌保护多靶作用机制的研究进展[J].医药导报,2018,37(2):165-171.
[12]章樱,陈国庆,张勤.磷酸肌酸钠对新生儿缺氧缺血性脑病氧化应激的影响及心肌损伤的保护作用[J].中华全科医学,2016,14(5):786-789.
[13]STRUMIA E,PELLICIA F,D’AMBROSIO G.Creatine phosphate:pharmacological and clinical perspectives[J].Adv Ther,2012,29(2):99-123.
[14]张会珍,邢艳秋,肖冬,等.磷酸肌酸联合缺血后适应对大鼠心肌缺血/再灌注损伤的保护作用[J].中国药理学通报,2012,28(11):1611-1614.
[15]邓小强,陈珂,姜徽,等.磷酸肌酸钠预先给药对2型糖尿病患者心肌缺血-再灌注损伤的影响[J].临床麻醉学杂志,2015,31(1):9-11.
[16]邹玲莉,李秋莎,等.离子对反相高效液相色谱法同时测定大鼠血浆和红细胞中外源性磷酸肌酸及其代谢产物和相关三磷酸腺苷[J].分析化学,2011,39(1):45-50.
[17]张燕,王文生,廉静,等.参附注射液联合磷酸肌酸钠治疗扩张型心肌病心功能不全效果[J].精准医学杂志,2018,33(3):256-258,262.
[18]石佳,袁素,薛庆华,等.冠心病患者围术期应用磷酸肌酸的心肌保护作用研究[J].中国分子心脏病学杂志,2010,10(1):44-47.
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