半夏泻心方在消化系统疾病中的应用及疗效机制研究进展
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摘要
对半夏泻心方(半夏泻心汤及其不同剂型统称半夏泻心方)在消化系统疾病的临床应用及作用机制研究进展进行综述。分析结果显示半夏泻心方临床主要用于消化系统疾病的治疗,其在慢性胃炎、消化性溃疡、功能性胃肠病、反流性食管炎、炎症性肠病、胃轻瘫综合征、消化道肿瘤及化疗所致的胃肠道反应等的治疗中应用最多;药理研究结果表明半夏泻心方具有保护消化道黏膜、抗炎杀菌、抗氧化应激、双向调节胃肠功能、调节肠道菌群等作用。
The clinical application and therapeutic mechanism of Banxia Xiexin Recipe(referring to Banxia Xiexin Decoction and its various preparation forms)in treating digestive system diseases were reviewed.The results showed that Banxia Xiexin Recipe is mainly used for the treatment of digestive system diseases such as chronic gastritis,peptic ulcer,functional gastrointestinal disorders,reflux esophagitis,inflammatory bowel disease,gastroparesis,gastrointestinal cancer and gastrointestinal reaction induced by chemotherapy,etc.The pharmacological research results showed that Banxia Xiexin Recipe can protect digestive tract mucosa,and has anti-inflammation and bactericidal action,anti-oxidative effects and bilateral regulation of gastrointestinal function,and regulatory effect on intestinal flora.
The clinical application and therapeutic mechanism of Banxia Xiexin Recipe(referring to Banxia Xiexin Decoction and its various preparation forms)in treating digestive system diseases were reviewed.The results showed that Banxia Xiexin Recipe is mainly used for the treatment of digestive system diseases such as chronic gastritis,peptic ulcer,functional gastrointestinal disorders,reflux esophagitis,inflammatory bowel disease,gastroparesis,gastrointestinal cancer and gastrointestinal reaction induced by chemotherapy,etc.The pharmacological research results showed that Banxia Xiexin Recipe can protect digestive tract mucosa,and has anti-inflammation and bactericidal action,anti-oxidative effects and bilateral regulation of gastrointestinal function,and regulatory effect on intestinal flora.
引文
[1]崔丽君,张艳,郑志娟,等.近六十年半夏泻心汤相关研究文献分析[J].西部中医药,2015,28(7):49.
[2]齐豫.基于半夏泻心汤Meta分析辛开苦降法研究[D].广州:广州中医药大学,2016.
[3]杨晋翔,安静,彭继升,等.半夏泻心汤加减方治疗慢性萎缩性胃炎临床疗效的系统评价[J].北京中医药大学学报,2015,38(1):48.
[4]黄停停,崔倩倩,赵文霞.改良半夏泻心汤联合四联疗法治疗幽门螺杆菌相关性慢性非萎缩性胃炎的临床观察[C]//第二十九届全国中西医结合消化系统疾病学术会议论文集. 2017:829-831.
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[6]彭国强,商建飞,杜杰,等.半夏泻心汤加减治疗Hp相关消化性溃疡的临床分析[J].中国实验方剂学杂志,2016,22(5):197.
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[8]刘添文,陈新林,缪旺冬,等.半夏泻心汤治疗腹泻型肠易激综合征临床观察[J].新中医,2016,48(8):76.
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[11] Careyva B,Stello B. Diabetes mellitus management of gastrointestinal complications[J]. Am Fam Physician,2016,94(12):980.
[12]侯言彬,楼忠泽,季蕴辛,等.半夏泻心汤联合米氮平对特发性胃轻瘫病患者胃肠激素和5-HT水平的影响[J].中国中西医结合消化杂志,2017,25(12):952.
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[14]李凯.辛开苦降法及半夏泻心汤治疗结肠癌的临床和基础研究[D].北京:中国中医科学院,2015.
[15]张晓丽,王明星. PoD加半夏泻心汤治疗老年人食管癌25例[J].辽宁中医杂志,1993,32(8):30.
[16]丰素娟.半夏泻心汤防治胃癌前病变的实验与临床研究[J].中成药,2000,22(8):48.
[17]刘晓霓,金秀东,李月珍,等.半夏泻心汤对反流性食管炎大鼠胃酸胆汁酸和CGRP的影响[J].放射免疫学杂志,2008,21(4):27.
[18]张忠,司银楚,白丽敏,等.半夏泻心汤及其拆方对应激性胃溃疡大鼠胃泌素的影响[J].世界华人消化杂志,2005,13(10):65.
[19]徐颖,张祖志,方正清,等.半夏泻心汤对应激性胃黏膜损伤大鼠血管活性肠肽含量的影响[J].中医药临床杂志,2004,16(2):3.
[20]张忠,司银楚,白丽敏,等.半夏泻心汤对应激性胃溃疡大鼠生长抑素的影响[J].中国中西医结合杂志,2007,27(10):52.
[21]王庆国,李宇航,牛欣,等.半夏泻心汤及其拆方对慢性胃溃疡大鼠表皮生长因子的影响[J].中国中西医结合急救杂志,2001,8(3):137.
[22]杨贵珍,郑月娟,姜昕,等.半夏泻心汤抑制巨噬细胞分泌促炎因子抗胃炎机制研究[J].中国中西医结合消化杂志,2015,23(3):14.
[23]杨贵珍,郑月娟,姜昕,等.半夏泻心汤调控巨噬细胞分泌HSP70抗Hp性胃炎作用机制研究[J].中国中西医结合消化杂志,2016,24(1):5.
[24] Chen G,Yang Y,Liu M,et al. Banxia Xiexin decoction protects against dextran sulfate sodium-induced chronic ulcerative colitis in mice[J]. J Ethnopharmacol,2015,166:149.
[25]崔国宁,刘喜平,李沛清,等.半夏泻心汤含药血清对胃癌微环境诱导人腹膜间皮细胞氧化应激反应的影响[J].时珍国医国药,2017,28(1):20.
[26]蒋锋利,王淑艳,李丽娜,等.半夏泻心汤及其拆方对胃肠平滑肌细胞增殖的影响[J].辽宁中医杂志,2015,42(8):170.
[27]王庆国,李宇航,赵琰,等.半夏泻心汤及其拆方对正常大鼠胃肠运动功能的影响[J].北京中医药大学学报,2001,24(6):22.
[28]刘珍,邓天好,尹抗抗,等.半夏泻心汤对脾虚便秘小鼠肠道细菌多样性的影响[J].湖南中医杂志,2017,33(10):162.
[2]齐豫.基于半夏泻心汤Meta分析辛开苦降法研究[D].广州:广州中医药大学,2016.
[3]杨晋翔,安静,彭继升,等.半夏泻心汤加减方治疗慢性萎缩性胃炎临床疗效的系统评价[J].北京中医药大学学报,2015,38(1):48.
[4]黄停停,崔倩倩,赵文霞.改良半夏泻心汤联合四联疗法治疗幽门螺杆菌相关性慢性非萎缩性胃炎的临床观察[C]//第二十九届全国中西医结合消化系统疾病学术会议论文集. 2017:829-831.
[5]刘余,龚后武,谭达全,等.半夏泻心汤加减治疗消化性溃疡的Meta分析[J].中华中医药杂志,2016,31(8):396.
[6]彭国强,商建飞,杜杰,等.半夏泻心汤加减治疗Hp相关消化性溃疡的临床分析[J].中国实验方剂学杂志,2016,22(5):197.
[7]李赛,李东.半夏泻心汤治疗功能性消化不良的系统评价[J].北京中医药,2016,35(5):50.
[8]刘添文,陈新林,缪旺冬,等.半夏泻心汤治疗腹泻型肠易激综合征临床观察[J].新中医,2016,48(8):76.
[9] Dai Y K, Zhang Y Z, Li D Y, et al. Efficacy and safety of modified Banxia Xiexin Decoction(Pinellia Decoction for Draining the Heart)for gastroesophageal reflux disease in adults:a systematic review and Meta-analysis[J]. Evid-Based Compl Alt Med,2017,2017(2):1
[10]裴强伟,孙志翠,宋小莉,等.半夏泻心汤及其加减方治疗溃疡性结肠炎疗效和安全性的系统评价[J].中国实验方剂学杂志,2012,18(14):300.
[11] Careyva B,Stello B. Diabetes mellitus management of gastrointestinal complications[J]. Am Fam Physician,2016,94(12):980.
[12]侯言彬,楼忠泽,季蕴辛,等.半夏泻心汤联合米氮平对特发性胃轻瘫病患者胃肠激素和5-HT水平的影响[J].中国中西医结合消化杂志,2017,25(12):952.
[13]王海威.加味半夏泻心汤治疗迟发性化疗相关性呕吐的临床研究[D].北京:北京中医药大学,2014.
[14]李凯.辛开苦降法及半夏泻心汤治疗结肠癌的临床和基础研究[D].北京:中国中医科学院,2015.
[15]张晓丽,王明星. PoD加半夏泻心汤治疗老年人食管癌25例[J].辽宁中医杂志,1993,32(8):30.
[16]丰素娟.半夏泻心汤防治胃癌前病变的实验与临床研究[J].中成药,2000,22(8):48.
[17]刘晓霓,金秀东,李月珍,等.半夏泻心汤对反流性食管炎大鼠胃酸胆汁酸和CGRP的影响[J].放射免疫学杂志,2008,21(4):27.
[18]张忠,司银楚,白丽敏,等.半夏泻心汤及其拆方对应激性胃溃疡大鼠胃泌素的影响[J].世界华人消化杂志,2005,13(10):65.
[19]徐颖,张祖志,方正清,等.半夏泻心汤对应激性胃黏膜损伤大鼠血管活性肠肽含量的影响[J].中医药临床杂志,2004,16(2):3.
[20]张忠,司银楚,白丽敏,等.半夏泻心汤对应激性胃溃疡大鼠生长抑素的影响[J].中国中西医结合杂志,2007,27(10):52.
[21]王庆国,李宇航,牛欣,等.半夏泻心汤及其拆方对慢性胃溃疡大鼠表皮生长因子的影响[J].中国中西医结合急救杂志,2001,8(3):137.
[22]杨贵珍,郑月娟,姜昕,等.半夏泻心汤抑制巨噬细胞分泌促炎因子抗胃炎机制研究[J].中国中西医结合消化杂志,2015,23(3):14.
[23]杨贵珍,郑月娟,姜昕,等.半夏泻心汤调控巨噬细胞分泌HSP70抗Hp性胃炎作用机制研究[J].中国中西医结合消化杂志,2016,24(1):5.
[24] Chen G,Yang Y,Liu M,et al. Banxia Xiexin decoction protects against dextran sulfate sodium-induced chronic ulcerative colitis in mice[J]. J Ethnopharmacol,2015,166:149.
[25]崔国宁,刘喜平,李沛清,等.半夏泻心汤含药血清对胃癌微环境诱导人腹膜间皮细胞氧化应激反应的影响[J].时珍国医国药,2017,28(1):20.
[26]蒋锋利,王淑艳,李丽娜,等.半夏泻心汤及其拆方对胃肠平滑肌细胞增殖的影响[J].辽宁中医杂志,2015,42(8):170.
[27]王庆国,李宇航,赵琰,等.半夏泻心汤及其拆方对正常大鼠胃肠运动功能的影响[J].北京中医药大学学报,2001,24(6):22.
[28]刘珍,邓天好,尹抗抗,等.半夏泻心汤对脾虚便秘小鼠肠道细菌多样性的影响[J].湖南中医杂志,2017,33(10):162.