戒毒一号对甲基苯丙胺诱导的小鼠行为敏化的影响
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摘要
目的探讨戒毒一号对甲基苯丙胺诱导的小鼠行为敏化的影响。方法分别采用单次给予甲基苯丙胺致小鼠高活动性及反复间断甲基苯丙胺处理建立甲基苯丙胺行为敏化小鼠模型,观察戒毒一号对甲基苯丙胺所致小鼠高活动性及其诱导的小鼠行为敏化的影响。结果戒毒一号低、高剂量灌胃给药后,对小鼠自发活动和甲基苯丙胺所致小鼠高活动性均无影响,却能显著抑制甲基苯丙胺诱导的小鼠行为敏化效应的形成、转化和表达。结论戒毒一号对甲基苯丙胺诱导的小鼠行为敏化的形成、转化和表达均有抑制作用,提示戒毒一号对甲基苯丙胺的精神依赖具有治疗作用。
Objective The aim of this study is to investigate the effects of Jieduyihao(JDYH)on the development,transfer and expression of methamphetamine(METH)-induced sensitization in mice.Methods The mice models of METH-induced hyperactivity with single dose administration andMETH-induced behavioral sensitization with repeated intermittent administration were established.The effects of JDYH on the METH-induced hyperactivity and sensitization in mice were observed.Results Compared with the control group,the locomotor activity and hyperactivity of mice have nochange after being treated with low-dose(14. 12 g/kg)and high-dose(56. 48 g/kg)of JDYH.Compared with the model group,the development,transfer and expression of METH-inducedsensitization in JDYH treated mice were significantly suppressed. Conclusion JDYH can extraordinaryinhibit the development,transfer and expression of METH-induced sensitization in mice,it suggeststhat JDYH may be a promising candidate for the management of METH addictions.
Objective The aim of this study is to investigate the effects of Jieduyihao(JDYH)on the development,transfer and expression of methamphetamine(METH)-induced sensitization in mice.Methods The mice models of METH-induced hyperactivity with single dose administration andMETH-induced behavioral sensitization with repeated intermittent administration were established.The effects of JDYH on the METH-induced hyperactivity and sensitization in mice were observed.Results Compared with the control group,the locomotor activity and hyperactivity of mice have nochange after being treated with low-dose(14. 12 g/kg)and high-dose(56. 48 g/kg)of JDYH.Compared with the model group,the development,transfer and expression of METH-inducedsensitization in JDYH treated mice were significantly suppressed. Conclusion JDYH can extraordinaryinhibit the development,transfer and expression of METH-induced sensitization in mice,it suggeststhat JDYH may be a promising candidate for the management of METH addictions.
引文
[1]郝柳,罗涛,唐爱国,等.甲基苯丙胺滥用的研究进展[J].中国药物滥用防治杂志,2015,21(5):302-306.
[2] HUANG X D,CHEN Y Y,SHEN Y,et al. Methamphetamine abuse impairs motor cortical plasticity and function[J].Molecular Psychiatry,2017,22(9):1274-1281.
[3]刘胜,周文华,杨国栋.成瘾药物行为敏化及机制[J].中国药物滥用防治杂志,2004,10(6):337-339.
[4] ZHAO N,CHEN Y,ZHU J,et al. Levo-tetrahydropalmatine attenuates the development and expression of methamphet?amine-induced locomotor sensitization and the accompanying activation of ERK in the nucleus accumbens and caudate puta?men in mice[J]. Neuroscience,2014,258(1):101-110.
[5]梁建辉,韩容.行为敏化动物模型在药物依赖性评价中的应用[J].中国药理学通报,2004,20(7):726-730.
[6] JING L,ZHANG M,LI J X,et al. Comparison of single versus repeated methamphetamine injection induced behavioralsensitization in mice[J]. Neuroscience Letters,2014,560:103-106.
[7] HO T J,LEE C W,LU Z Y,et al. Effects of electroacupuncture on methamphetamine-induced behavioral changes in mice[J].Evid Based Complement Alternat Med,2017(2):5642708.
[8]吴金涛.褪黑素对甲基苯丙胺致行为敏化和神经毒性的干预作用及其机制研究[D].济南:山东大学,2017.
[9] UJIKE H,ONOUE T,AKIYAMA K,et al. Effects of selective D-1 and D-2 dopamine antagonists on development of meth?amphetamine-induced behavioral sensitization[J]. Psychopharmacology, 1989,98(1):89-92.
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[11] HUANG M,KONG L,YANG L,et al. The role of thioredoxin-1 in resisting methamphetamine-induced rewarding effect[J]. Behavioural Brain Research,2017,30(1):280-286.
[12] LONDON E D,KOHNO M,MORALES A M,et al. Chronic methamphetamine abuse and corticostriatal deficits revealed byneuroimaging[J]. Brain Research,2015,1628:174-185.
[13] KELLY M A,LOW M J,RUBINSTEIN M,et al. Role of dopamine D1-like receptors in methamphetamine locomotorresponses of D2 receptor knockout mice[J]. Genes Brain Behav,2008,7(5):568-577.
[14] YUN J. L-tetra hydropalmatine inhibits methamphetamine-induced locomotor activity via regulation of 5-HT neuronal activi?ty and dopamine D3 receptor expression[J]. Phytomedicine International Journal of Phytotherapy&Phytopharmacology,2014,21(11):1287-1291.
[15] SU H L,ZHU J,CHEN Y J,et al. Roles of levo-tetrahydropalmatine in modulating methamphetamine reward behavior[J].Physiology&Behavior,2013,118(7):195-200.
[16] HU J Y,JIN G Z. Supraspinal D2 receptor involved in antinociception induced by l-tetrahydropalmatine[J]. Zhongguo YaoLI Xue Bao,1999,20(8):715-719.
[17]赵娜,王亮,朱杰,等.左旋四氢巴马汀降低MA引起的小鼠行为敏化及ERK磷酸化表达的增加[J].中国药物依赖性杂志,2010,19(5):421-422.
[18]游秋云,王平.茯苓、茯神水煎液对小鼠镇静催眠作用的比较研究[J].湖北中医药大学学报,2013,15(2):15-17.
[19]祝洪艳,何忠梅,王国丽,等.参芪五味子片对神经系统的药理作用及临床研究[J].吉林中医药,2014,34(8):842-844.
[20]刘云芳,钱凌,过伟峰.药食两用复方颗粒剂治疗心神失养型亚健康失眠的临床研究[J].广州中医药大学学报,2016,33(5):621-625.
[21]白明.中西医结合治疗睡眠障碍综合征临床研究[J].中医学报,2013,28(10):1564-1565.
[22]赵晋炜,程景民. 18种单味中药提取物抗惊厥作用的药效学比较研究[J].中西医结合心脑血管病杂志,2015(5):593-596.
[23]王炎.补气生血说党参[J].食品与健康,2016(8):21-21.
[24]李岩,武乾,林谦.补气药党参黄芪对慢性心衰大鼠血流动力学的影响[J].中国中医基础医学杂志,2010,16(7):597-598.
[25]李忠.药膳常用中药[J].抗癌之窗,2011(5):64-65.
[26]饶润珍.四君子汤在耳鼻喉科的临床应用[J].大家健康(旬刊),2017,11(3):53-53.
[27]何席呈,孙庆文,董立莎,等. 28个不同采集地土茯苓(断面红色、白色)中落新妇苷分析及抗炎作用的比较[J].中国中药杂志,2012,37(23):3595-3598.
[2] HUANG X D,CHEN Y Y,SHEN Y,et al. Methamphetamine abuse impairs motor cortical plasticity and function[J].Molecular Psychiatry,2017,22(9):1274-1281.
[3]刘胜,周文华,杨国栋.成瘾药物行为敏化及机制[J].中国药物滥用防治杂志,2004,10(6):337-339.
[4] ZHAO N,CHEN Y,ZHU J,et al. Levo-tetrahydropalmatine attenuates the development and expression of methamphet?amine-induced locomotor sensitization and the accompanying activation of ERK in the nucleus accumbens and caudate puta?men in mice[J]. Neuroscience,2014,258(1):101-110.
[5]梁建辉,韩容.行为敏化动物模型在药物依赖性评价中的应用[J].中国药理学通报,2004,20(7):726-730.
[6] JING L,ZHANG M,LI J X,et al. Comparison of single versus repeated methamphetamine injection induced behavioralsensitization in mice[J]. Neuroscience Letters,2014,560:103-106.
[7] HO T J,LEE C W,LU Z Y,et al. Effects of electroacupuncture on methamphetamine-induced behavioral changes in mice[J].Evid Based Complement Alternat Med,2017(2):5642708.
[8]吴金涛.褪黑素对甲基苯丙胺致行为敏化和神经毒性的干预作用及其机制研究[D].济南:山东大学,2017.
[9] UJIKE H,ONOUE T,AKIYAMA K,et al. Effects of selective D-1 and D-2 dopamine antagonists on development of meth?amphetamine-induced behavioral sensitization[J]. Psychopharmacology, 1989,98(1):89-92.
[10] UNO K,MIYAZAKI T,SODEYAMA K,et al. Methamphetamine induces Shati/Nat8L expression in the mouse nucleusaccumbens via CREB-and dopamine D1 receptor-dependent mechanism[J]. Plos One, 2017,12(3):e174196.
[11] HUANG M,KONG L,YANG L,et al. The role of thioredoxin-1 in resisting methamphetamine-induced rewarding effect[J]. Behavioural Brain Research,2017,30(1):280-286.
[12] LONDON E D,KOHNO M,MORALES A M,et al. Chronic methamphetamine abuse and corticostriatal deficits revealed byneuroimaging[J]. Brain Research,2015,1628:174-185.
[13] KELLY M A,LOW M J,RUBINSTEIN M,et al. Role of dopamine D1-like receptors in methamphetamine locomotorresponses of D2 receptor knockout mice[J]. Genes Brain Behav,2008,7(5):568-577.
[14] YUN J. L-tetra hydropalmatine inhibits methamphetamine-induced locomotor activity via regulation of 5-HT neuronal activi?ty and dopamine D3 receptor expression[J]. Phytomedicine International Journal of Phytotherapy&Phytopharmacology,2014,21(11):1287-1291.
[15] SU H L,ZHU J,CHEN Y J,et al. Roles of levo-tetrahydropalmatine in modulating methamphetamine reward behavior[J].Physiology&Behavior,2013,118(7):195-200.
[16] HU J Y,JIN G Z. Supraspinal D2 receptor involved in antinociception induced by l-tetrahydropalmatine[J]. Zhongguo YaoLI Xue Bao,1999,20(8):715-719.
[17]赵娜,王亮,朱杰,等.左旋四氢巴马汀降低MA引起的小鼠行为敏化及ERK磷酸化表达的增加[J].中国药物依赖性杂志,2010,19(5):421-422.
[18]游秋云,王平.茯苓、茯神水煎液对小鼠镇静催眠作用的比较研究[J].湖北中医药大学学报,2013,15(2):15-17.
[19]祝洪艳,何忠梅,王国丽,等.参芪五味子片对神经系统的药理作用及临床研究[J].吉林中医药,2014,34(8):842-844.
[20]刘云芳,钱凌,过伟峰.药食两用复方颗粒剂治疗心神失养型亚健康失眠的临床研究[J].广州中医药大学学报,2016,33(5):621-625.
[21]白明.中西医结合治疗睡眠障碍综合征临床研究[J].中医学报,2013,28(10):1564-1565.
[22]赵晋炜,程景民. 18种单味中药提取物抗惊厥作用的药效学比较研究[J].中西医结合心脑血管病杂志,2015(5):593-596.
[23]王炎.补气生血说党参[J].食品与健康,2016(8):21-21.
[24]李岩,武乾,林谦.补气药党参黄芪对慢性心衰大鼠血流动力学的影响[J].中国中医基础医学杂志,2010,16(7):597-598.
[25]李忠.药膳常用中药[J].抗癌之窗,2011(5):64-65.
[26]饶润珍.四君子汤在耳鼻喉科的临床应用[J].大家健康(旬刊),2017,11(3):53-53.
[27]何席呈,孙庆文,董立莎,等. 28个不同采集地土茯苓(断面红色、白色)中落新妇苷分析及抗炎作用的比较[J].中国中药杂志,2012,37(23):3595-3598.