以医院为基础的宫颈癌登记患者生存率分析

详细信息    查看全文 | 推荐本文 |

英文篇名：Analysis of survival rate of registered patients with cervical cancer based on hospitals 作者：陈海珍 ; 陈建国 ; 施民新 ; 朱健 ; 倪倬健 ; 杨晓梅 ; 邵晶晶 ; 陆云燕 ; 冒小平 英文作者：CHEN Hai Zhen;CHEN Jian Guo;SHI Min Xin;ZHU Jian;NI Zhuo Jian;YANG Xiao Mei;SHAO Jing Jing;LU Yun Yan;MAO Xiao Ping;Nantong University Tumor Hospital/Institute;Qidong Liver Cancer Insitutute;Haimen City Center for Disease Control and Prevention; 关键词：宫颈癌 ; 肿瘤登记 ; 随访 ; 生存率 英文关键词：cervical cancer;;cancer registration;;follow-up;;survival rate 中文刊名：YZWS 英文刊名：Chinese Journal of Women and Children Health 机构：江苏省南通市肿瘤医院/南通大学附属肿瘤医院;江苏省启东肝癌防治研究所;江苏省海门市疾病预防控制中心; 出版日期：2019-01-20 出版单位：中国妇幼卫生杂志 年：2019 期：v.10 基金：南通市社会事业科技创新与示范项目(qyz15017);; 南通市医学重点人才项目(重点:36) 语种：中文; 页：YZWS201901004 页数：5 CN：01 ISSN：11-5816/R 分类号：20-24

摘要

目的对南通市肿瘤医院2002-2014年以医院为基础的宫颈癌登记病例作生存率分析,为宫颈癌防治提供依据。方法采用主动随访与被动随访相结合的方法,对建立的以医院为基础的癌症登记数据库中来自启东、海门籍的宫颈癌住院患者开展生存结局的随访,随访截至2016年3月31日。用寿命表法计算各年观察生存率,并采用SPSS21软件作生存率比较分析,并用Gehan统计量评估差异的显著性。结果在南通市肿瘤医院住院的启东、海门籍宫颈癌患者为452例,随访获得癌症生存结局信息的为432例,随访率为95. 58%;失访20例,失访率为4. 42%。首次入院平均年龄为(51. 59±7. 07)岁。在各年龄组中40～59岁共计276例,占63. 89%。患者的1、3、5及10年总观察生存率分别为88. 43%、72. 74%、66. 58%及58. 01%。<40岁组、40～49岁组、50～59岁组、60～69岁组及≥70岁组的5年总观察生存率分别为68. 17%、75. 77%、68. 57%、54. 52%及43. 42%;<40岁组与60～69岁组生存率比较(Gehan=6. 144,P=0. 013)、40～49岁组与60～69岁组生存率比较(Gehan=4. 624,P=0. 032),差异均有统计学意义(P <0. 05)。启东籍宫颈癌患者1年、3年观察生存率略高于海门籍患者,而5年及10年观察生存率则低于海门籍患者,但差异无统计学意义(P> 0. 05)。结论本组以医院为基础的宫颈癌登记患者地区间差异不大,但各年龄组生存率比较差异有统计学意义。较高的患者随访率,完整体现了启海籍宫颈癌患者治疗的综合效果。
        Objective To analyze survival rates of registered cases of cervical cancer based on hospital in Nantong Cancer Hospital from 2002 to 2014 in order to provide basis for the evaluation of prognosis of cervical cancer. Methods Active follow-up and passive follow-up methods were used to obtain the information on the survival outcomes of hospitalized patients with cervical cancer from Qidong and Haimen in a hospital-based cancer registry. Follow-up ended on 31 March 2016. Survival probability was estimated using the lifetable method,and comparison was made by Gehan statistics. Results The outcomes of 432 patients were identified in the follow-up of452 cases from Qidong and Haimen,with a follow-up rate of 95. 58%,and a loss rate of 4. 42%(20 cases). The average age of the first-hospitalization was(51. 59 ± 7. 07) years old. The most commonly affected ages were 40-59 years old,accounting for 63. 89%.The 1-,3-,5-,and 10-year observed survival(OS) rate of cervical cancer were 88. 43%,72. 74%,66. 58% and 58. 01%,respectively. The 5-year OS rates of cervical cancer at age groups of 0-39,40-49,50-59,60-69,70+years were 68. 17%,75. 77%,68. 57%,54. 52% and 43. 42%,respectively. There were significant differences in overall OS rates at two age groups: 0-39 and 60-69 years old(Gehan = 6. 144,P = 0. 013); 40-49 and 60-69 years old(Gehan = 4. 624,P = 0. 032). Patients from Qidong seem to have experienced better survival than those patients from Haimen for the 1-,3-year OS rates,while the 5-,10-year OS rates seem little higher in patients from Haimen,but no significant differences were found(P > 0. 05). Conclusion There were no significant differences in overall OS rates between patients with cervical cancer from Qidong city and Haimen city,but the singnificant differences exist among age groups. Due to the high follow-up rate of patients,this study fully reflects the comprehensive effect of the treatment of Qidong-Haimen patients with cervical cancer patients at our hospital.

引文

[1] Siegel RL,Miller KD,Jemal A. Cancer statistics,2016[J]. CA Cancer J Clin,2016,66(1):7-30.
    [2] Hu SY,Zheng RS,Zhao FH,et al. Trend analysis of cervical cancer incidence and mortality rates in Chinese women during 1989-2008[J]. Acta Acad Med Sin,2014,36(2):119-125.
    [3]陈海珍,岳增军,陈建国,等. 2002-2012年南通市肿瘤医院癌症住院患者分布特征分析[J].中华肿瘤防治杂志,2015,22(12):901-906.
    [4] Parkin DM,Hakulinen T. Chapter 12. Analysis of survival. In:Jensen OM,Parkin MD,MacLennan R,eds.Cancer Registration:Principles and Methods[M].IARC Sci Publ No. 95,Lyon:IARC,1991:159-176.
    [5]陈建国,沈福民.生存率分析的资料收集及常用方法[J].中华疾病控制杂志,1998,2(3):222-227.
    [6] Arbyn M,de Saraiya M. EUROGIN 2011 roadmap on prevention and treatment of HPV-related disease[J].Int J Cancer,2012,131(9):1969-1982.
    [7]赫捷,陈万青. 2012中国肿瘤登记年报[M].北京:军事医学科学出版社,2012.
    [8]陈万青,孙可欣,郑荣寿,等. 2014年中国分地区恶性肿瘤发病和死亡分析[J].中国肿瘤,2018,27(1):1-14.
    [9]丁璐璐,朱健,张永辉.等. 1972-2011年江苏省启东市1 211例宫颈癌患者生存率分析[J].中国妇幼保健,2017,32(4):648-650.
    [10]陈建国.启东癌症报告1972-2013[M].北京:军事医学科学出版社. 2013:1-346.
    [11]王静,许可葵,史百高,等. 4374例宫颈癌患者预后及其影响因素分析[J].中国肿瘤,2014,23(4):281-288.
    [12]程静新,姚立丽,李贺月,等. 5766例宫颈癌临床特征分析[J].实用妇产科杂志,2014,30(10):768-771.
    [13]刘可佳,李永红.同步放化疗在中晚期宫颈癌治疗中的疗效及安全性观察[J].中国实用医药,2016,11(8):158-159.
    [14] Allemani C,Weir HK,Carreira H,et al. Global surveillance of cancer survival 1995-2009:analysis of individual data for 25,676,887 patients from 279 population-based registries in 67 countries(CONCORD-2)[J]. Lancet,2015,385(9972):977-1010.
    [15]陈晓红.青年妇女患宫颈癌的临床研究及预后分析[J].现代预防医学,2012,39(22):5832-5834.
    [16]陆云燕.ⅠB2期子宫颈鳞癌患者新辅助化疗后淋巴结转移情况临床分析[J].中华临床医师杂志,2014,8(19):3575-3577.
    [17]邵佳,何爱琴,陈曾燕.局部晚期宫颈癌术前同步放化疗疗效及安全性评价[J].中国肿瘤外科杂志,2014,6(5):282-287.
    [18]朱健,张永辉,陈永胜,等.启东市2001-2007年宫颈癌生存率分析[J].中国肿瘤临床与康复,2011,18(3):193-196.