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间充质干细胞治疗诱导单核细胞/巨噬细胞表型转换作用的研究进展
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  • 作者:吴菲菲 ; 季晶晶 ; 陆文彬 ; 马根山
  • 关键词:心肌梗死 ; 间充质干细胞 ; 单核细胞 ; 巨噬细胞 ; 综述
  • 中文刊名:NJTD
  • 英文刊名:Journal of Southeast University(Medical Science Edition)
  • 机构:东南大学医学院;东南大学附属中大医院心血管内科;
  • 出版日期:2019-04-25
  • 出版单位:东南大学学报(医学版)
  • 年:2019
  • 期:v.38;No.174
  • 基金:国家自然科学基金资助项目(81670326)
  • 语种:中文;
  • 页:NJTD201902031
  • 页数:5
  • CN:02
  • ISSN:32-1647/R
  • 分类号:167-171
摘要
急性心肌梗死(AMI)后心肌细胞凋亡坏死,不能有效代偿,引起心肌重塑,导致心力衰竭的发展。为了减少瘢痕组织形成并刺激心脏组织的再生,间充质干细胞(MSC)已经在AMI后应用并且显示出对心脏功能的益处。研究发现AMI后对炎症反应的调节,特别是与单核细胞/巨噬细胞的作用相关,是MSC治疗的重要方面。单核细胞和巨噬细胞用不同表型刺激或抑制炎症与心肌重塑,对心血管疾病病理生理学的重要贡献引起了人们的极大关注。为了更深入地了解MSC的这种作用,在本文中作者就MSC对单核细胞/巨噬细胞的这种调节作用作一综述。
        
引文
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