中国湖南地区痴呆患者的疾病特征及相关危险因素分析

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英文篇名：Characteristics and related risk factors of dementia patients in Hunan, China 作者：周亚芳 ; 乌新微 ; 周路 ; 唐北沙 ; 沈璐 英文作者：Zhou Ya-fang;Wu Xin-wei;Zhou Lu;Tang Bei-sha;Shen Lu;National Clinical Research Center for Geriatric Disorders, Central South University;Department of Neurology, Xiangya Hospital, Central South University;National Clinical Research Center for Geriatric Disorders; 关键词：痴呆 ; 危险因素 ; MMSE ; HAMD 英文关键词：dementia;;risk factors;;MMSE;;HAMD 中文刊名：AAEC 英文刊名：Chinese Journal of Alzheimer's Disease and Related Disorders 机构：中南大学湘雅医院老年病学神经内科;中南大学湘雅医院神经内科;国家老年疾病临床医学研究中心(湘雅); 出版日期：2019-04-15 出版单位：阿尔茨海默病及相关病 年：2019 期：v.2;No.5 语种：中文; 页：AAEC201902007 页数：5 CN：02 ISSN：10-1536/R 分类号：33-37

摘要

目的:发现中国湖南地区痴呆患者的疾病特征,并进行痴呆的相关危险因素分析。方法:纳入中南大学湘雅医院神经内科记忆障碍门诊2004年2月至2018年7月就诊的湖南省痴呆患者,收集患者的一般信息、病史等资料,运用MMSE量表评估患者认知功能,HAMD量表评估抑郁程度。结果:本研究共纳入痴呆患者1239例,其中男性571例,女性668例;平均发病年龄65.7±11.1岁,平均病程3.5±2.8年,39.5%的患者受教育水平为初中及以下。痴呆疾病类型以阿尔茨海默病为主,占69%。MMSE平均12.3±8.5分。Pearson相关分析结果显示,患者发病年龄与MMSE评分具有低度负相关性,而病程与MMSE存在中度负相关。多元线性回归结果显示,痴呆患者文化程度和HAMD评分对MMSE评分在总体中存在显著的线性关系。结论:通过对中国湖南地区痴呆患者的研究,总结了该地区痴呆的疾病类型及疾病特点,发现痴呆患者的发病年龄和病程与痴呆的严重程度具有相关性,而低文化程度,高HAMD得分是导致认知功能障碍严重的危险因素。
        Objective To analyze the characteristics and related risk factors of dementia patients in Hunan, China. Methods The patients with dementia in Hunan Province admitted to Neurology Memory Disorder Clinic of Xiangya Hospital of Central South University from February 2004 to July 2018 were enrolled. General information and medical history of the patients were collected. The cognitive function of the patients was assessed by MMSE scale, and the degree of depression was assessed by HAMD scale.Results A total of 1239 dementia patients were included in this study, including 571 males and 668 females. The average age of onset was 65.7 + 11.1 years, the average course of disease was 3.5 + 2.8 years, and 39.5% of the patients had education level below junior middle school. Alzheimer's disease is the main type of dementia, accounting for 69%. The average score of MMSE was 12.3 + 8.5. Pearson correlation analysis showed that there was a low negative correlation between age of onset and MMSE score, and a moderate negative correlation between duration and MMSE score. Multivariate linear regression showed that there was a significant linear relationship between education level and HAMD score and MMSE score in dementia patients. Conclusions Through this study of dementia patients in Hunan, China, the types and characteristics of dementia in this area were summarized. It was found that the age and course of dementia patients were related to the severity of dementia. Low educational level and high HAMD score were the risk factors for serious cognitive impairment.

引文

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