长链非编码RNA在脓毒症肺损伤中作用的研究进展
摘要
长链非编码RNA(LncRNA)的生物功能多种多样,在转录的招募、表达、转录后修饰及表观遗传等过程中调控特异性基因的表达,广泛参与机体各种生理和病理过程。脓毒症是一种以器官功能障碍和对感染的异常免疫反应为特征的综合征。脓毒症引起的急性肺损伤/急性呼吸窘迫综合征(ALI/ARDS)发病率和死亡率较高。发生于肺部感染或肺外感染后,宿主对感染的异常反应导致肺泡毛细血管屏障破裂,导致肺损伤,表现为低氧血症、炎症和非心源性肺水肿。目前ALI/ARDS的发病机制尚不清楚,缺乏特异性的治疗方法。本文综述lncRNA在调控巨噬细胞、上皮细胞、内皮细胞、成纤维细胞等方面的研究进展,以期为lncRNA在脓毒症肺损伤的研究提供参考。
引文
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[4]Chen ZJMM. Progress and prospects of long noncoding RNAs in lipid homeostasis[J]. Molecular Metabolism,2016,5(3):164-170.
[5]王俊,周凯.长链非编码RNA在结直肠癌中的研究进展[J].江西医药,2014,49(10):1118-1120.
[6]Cui H,Banerjee S,Guo S,et al. Long noncoding RNA Malat1regulates differential activation of macrophage and response to lung injury[J]. JCI Insight,2019,4(4):e124522.
[7]Dai L,Zhang G,Cheng Z,et al. Knockdown of LncRNA MALAT1contributes to the suppression of inflammatory responses by upregulating miR-146a in LPS-induced acute lung injury[J].Connect Tissue Res,2018,59(6):581-592.
[8]Jia Y,Li Z,Cai W,et al. SIRT1 regulates inflammation response of macrophages in sepsis mediated by long noncoding RNA[J].Biochim Biophys Acta Mol Basis Dis,2018,1864(3):784-792.
[9]Scacalossi KR,van Solingen C,Moore KJ. Long non-coding RNAs regulating macrophage functions in homeostasis and disease[J].Vascul Pharmacol,2019,114:122-130.
[10]Zhang D,Lee H,Haspel JA,et al. Long noncoding RNA FOXD3-AS1 regulates oxidative stress-induced apoptosis via sponging microRNA-150[J]. Faseb J,2017,31(10):4472-4481.
[11]Li H,Shi H,Gao M,et al. Long non-coding RNA CASC2improved acute lung injury by regulating miR-144-3p/AQP1 axis to reduce lung epithelial cell apoptosis[J]. Cell Biosci,2018,8:15.
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[13]Li H,Shi H,Ma N,et al. BML-111 alleviates acute lung injury through regulating the expression of lncRNA MALAT1[J]. Arch Biochem Biophys,2018,649:15-21.
[14]Wang D,Gu C,Liu M,et al. Analysis of Long Noncoding RNA Expression Profile in Human Pulmonary Microvascular Endothelial Cells Exposed to Lipopolysaccharide[J]. Cell Physiol Biochem,2019,52(4):653-667.
[15]Rapicavoli NA,Qu K,Zhang J,et al. A mammalian pseudogene lncRNA at the interface of inflammation and anti-inflammatory therapeutics[J]. Elife,2013,2:e00762.
[16]Zhou Z,Zhu Y,Gao G,et al. Long noncoding RNA SNHG16targets miR-146a-5p/CCL5 to regulate LPS-induced WI-38 cell apoptosis and inflammation in acute pneumonia[J]. Life Sci,2019,228:189-197.
[17]Hu G,Tang Q,Sharma S,et al. Expression and regulation of intergenic long noncoding RNAs during T cell development and differentiation[J]. Nat Immunol,2013,14(11):1190-1198.
[18]蒋光辉,刘素芸,陶文强,等. SP-D、KL-6评价呼吸机相关性肺损伤的初步研究[J].江西医药,2017,52(12):1268-1270,1288.
[19]Wang L,Zhang N,Zhang Y,et al. Landscape of transcription and long non-coding RNAs reveals new insights into the inflammatory and fibrotic response following ventilator-induced lung injury[J].Respir Res,2018,19(1):122.
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