云南省德宏州2017年新报告HIV感染者病毒载量基线分析

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英文篇名：Baseline analysis on viral load of newly reported HIV-infected patients in Dehong Dai and Jingpo Autonomous prefecture, Yunnan, 2017 作者：杨世江 ; 陈晓晨 ; 段星 ; 王继宝 ; 乔世杰 ; 王译葵 ; 叶润华 ; 杨跃诚 ; 潘品良 ; 蒋岩 ; 姚仕堂 ; 何纳 ; 段松 英文作者：YANG Shijiang;CHEN Xiaochen;DUAN Xing;WANG Jibao;QIAO Shijie;WANG Yikui;YE Runhua;YANG Yuecheng;PAN Pinliang;JIANG Yan;YAO Shitang;HE Na;DUAN Song;Dehong Prefecture Center for Disease Control and Prevention;Department of Epidemiology,School of Public Health,and the Key Laboratory for Public Health Safety of Ministry of Education,Fudan University;National Center for AIDS/STD Control and Prevention,Chinese Center for Disease Control and Prevention; 关键词：艾滋病病毒 ; 新报告 ; 病毒载量 ; 基线 英文关键词：HIV;;viral load;;newly reported;;baseline 中文刊名：XBYA 英文刊名：Chinese Journal of AIDS & STD 机构：德宏傣族景颇族自治州疾病预防控制中心;复旦大学公共卫生学院流行病学教研室公共卫生安全教育部重点实验室;中国疾病预防控制中心性病艾滋病预防控制中心; 出版日期：2019-07-26 出版单位：中国艾滋病性病 年：2019 期：v.25;No.190 基金：国家“十二五”科技重大专项(2012ZX10001001-010-002);; 国家科技重大专项(2013zx10004-906)~~ 语种：中文; 页：XBYA201907009 页数：4 CN：07 ISSN：11-4818/R 分类号：31-34

摘要

目的了解2017年德宏傣族景颇族自治州(简称德宏州)新报告中国籍艾滋病病毒(HIV)感染者的病毒载量基线等情况,为艾滋病的预防和抗病毒治疗研究提供依据。方法对2017年德宏州新报告中国籍HIV感染者进行病毒载量检测,描述比较其人口学特征和病毒载量基线分布。结果 2017年德宏州新报告中国籍HIV感染者383例,其中370例(96.6%)进行病毒载量检测;少数民族占51.9%,小学及以下占52.2%,已婚有配偶占52.2%,异性性传播占88.0%。不同病毒载量除在民族、CD4~+T淋巴细胞(简称CD4细胞)计数中分布有差异外,在其他人口学特征中差异无统计学意义。中位数病毒载量Log_(10)值为4.1(四分位间距:3.3～4.7)拷贝/mL,男性的病毒载量Log_(10)值的中位数为[4.2(四分位间距:3.5～4.8)]拷贝/mL,显著高于女性的[3.9(四分位间距:3.2～4.5)]拷贝/mL。病毒载量与CD4细胞计数呈负相关关系(r~2=-0.30,P<0.001)。6例(1.6%)病毒载量为低于检测限的HIV感染者均为男性,其中4例HIV感染者的CD4细胞计数>500个/μL。结论德宏州新报告HIV感染者的病毒复制水平高,应尽早进行抗病毒治疗以期提高患者生存率。
        Objective To determine the demographic characteristics and viral load of Chinese HIV-infected patients in Dehong prefecture, Yunnan province in 2017, and to provide evidence for improving HIV prevention and treatment. Methods The viral load of newly reported Chinese HIV-infected patients was obtained and the demographic characteristics and viral load distribution were analyzed. Results In 2017, 383 Chinese HIV-infected patients were reported, of which 370(96.6%) were tested for viral load; 51.9% were minority; 52.2% had education level of elementary school; 52.2% were married and 88.0% heterosexual. There were significant differences in the distribution of different viral load groups in race and CD4 lymphocytes counts. The median virus load was 4.1(IQR: 3.3-4.7) lg(copies/mL), and the virus load of male[4.2(IQR: 3.5-4.8)] was significantly higher than that of female[3.9(IQR: 3.2-4.5)]. There was a negative correlation between viral load and CD4 lymphocytes counts(r~2=-0.30, P< 0.001). Six(1.6%) HIV-infected patients with viral load TND were male, and 4 patients had CD4 lymphocytes counts>500 cells/μL. Conclusion Dehong newly reported HIV-infected patients have high levels of viral replication, and antiviral therapy should be implemented as soon as possible to improve the survival rate of patients.

引文

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