运用限制性抗原亲和力酶联免疫法估计云南省德宏州婚检与孕产妇人群HIV新近感染率
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摘要
目的了解云南省德宏傣族景颇族自治州(简称德宏州)2009—2017年婚检与孕产妇人群艾滋病病毒(HIV)新发感染情况。方法婚检人群血浆样本210 486份和孕产妇血浆样本220 703份进行HIV检测,婚检和孕产妇人群HIV检测阳性分别为1 409例和1 475例。对德宏州2009—2017年血浆样本符合新发感染检测条件的388例婚检人群和336例孕产妇人群HIV阳性样本进行限制性抗原亲和力酶联免疫法检测以确定HIV新近感染,估计婚检人群和孕产妇HIV新近感染率。结果 2009—2017年婚检人群各年度HIV新近感染率分别为0.01%、0.04%、0.02%、0.05%、0.05%、0.08%、0.01%、0.03%和0.01%,总体相对稳定,差异无统计学意义(χ~2=13.805,P>0.05)。2009—2017年各年度孕产妇人群HIV新近感染率分别为0.02%、0.11%、0.07%、0.04%、0.04%、0.08%、0.02%、0.04%和0.04%,总体相对稳定,差异有统计学意义(χ~2=15.608,P<0.05)。结论德宏州2009—2017年婚检与孕产妇人群HIV新近感染率均保持较稳定的水平。
Objective To estimate the HIV incidence among people receiving premarital physical examination and pregnant women in Dehong prefecture, Yunnan province during 2009-2017. Methods 210 486 and 220 703 plasma samples were tested for HIV respectively from people receiving premarital physical examination and pregnant women during the period, among which 1 409 and 1 475 were HIV positive. 388 and 336 plasma samples were eligible for detection of new infections by using LAg-Avidity EIA, and HIV incidences were then estimated. Results Among people receiving premarital physical examination, the estimated HIV incidence from 2009 to 2017 was 0.01%, 0.04%, 0.02%, 0.05%, 0.05%, 0.08%, 0.01%, 0.03%, and 0.01%, respectively, with no significant difference(P=0.087). As for pregnant women, the estimated HIV incidence from 2009 to 2017 was 0.02%, 0.11%, 0.07%, 0.04%, 0.04%, 0.08%, 0.02%, 0.04% and 0.04%, respectively, with significant difference(P=0.048). Conclusion HIV incidences among people receiving premarital physical examination and pregnant women in Dehong prefecture remain relatively stable during 2009-2017.
Objective To estimate the HIV incidence among people receiving premarital physical examination and pregnant women in Dehong prefecture, Yunnan province during 2009-2017. Methods 210 486 and 220 703 plasma samples were tested for HIV respectively from people receiving premarital physical examination and pregnant women during the period, among which 1 409 and 1 475 were HIV positive. 388 and 336 plasma samples were eligible for detection of new infections by using LAg-Avidity EIA, and HIV incidences were then estimated. Results Among people receiving premarital physical examination, the estimated HIV incidence from 2009 to 2017 was 0.01%, 0.04%, 0.02%, 0.05%, 0.05%, 0.08%, 0.01%, 0.03%, and 0.01%, respectively, with no significant difference(P=0.087). As for pregnant women, the estimated HIV incidence from 2009 to 2017 was 0.02%, 0.11%, 0.07%, 0.04%, 0.04%, 0.08%, 0.02%, 0.04% and 0.04%, respectively, with significant difference(P=0.048). Conclusion HIV incidences among people receiving premarital physical examination and pregnant women in Dehong prefecture remain relatively stable during 2009-2017.
引文
[1] 陈敏,杨莉,杨朝军,等.2001—2010年云南省孕产妇哨点HIV-1感染率和新发感染率监测结果分析[J].中华预防医学杂志,2015,49(6):132-133.
[2] 龚渝蓉,徐梦娇,杨跃诚,等.德宏州2012—2015年婚检人群的HIV感染率及其影响因素[J].中国艾滋病性病,2017,23(5):405-408.
[3] UNAIDS Reference Group on Estimates Modelling and Projections.Statement on the use of the BED-assay for the estimation of HIV-1 incidence for surveillance or epidemic monitoring[J].WklyEpidemiol Rec,2006(81):40-41.
[4] Wei X,Liu X,Dobbs T,et al.Development of two avidity-based assays to detect recent HIV type 1 seroconversion using a multi-subtype gp41 recombinant protein[J].AIDS research and human retroviruses,2010,26(1):61-71.
[5] 中国疾病预防控制中心.全国艾滋病检测技术规范(2015年修订版)[J].中国病毒病杂志,2016,6(6):401-427.
[6] Duan S,Shen S,Bulterys M,et al.Estimation of HIV-1 incidence among five focal populations in Dehong,Yunnan:a hard hit area along a major drug trafficking route[J].BMC Public Health,2010,10(1):180.
[7] 罗小峰.德宏州饮酒与艾滋病相关高危行为及病程关系的流行病学研究[D].上海:复旦大学,2013.
[8] 段松,郭浩岩,庞琳,等.云南省德宏州艾滋病传播模式分析[J].中华预防医学杂志,2008,42(12):866-869.
[9] 段松,项丽芬,杨跃诚,等.云南省德宏州静脉注射毒品者HIV新发感染率及其危险因素研究[J].中华流行病学杂志,2009,30(12):1226-1229.
[10] Laeyendecker O,Brookmeyer R,Oliver AE,et al.Factors associated with incorrect identification of recent HIV infection using the BED capture immunoassay[J].AIDS research and human retroviruses,2012,28(8):816-822.
[11] Suligoi B,Buttò S,Galli C,et al.Detection of recent HIV infections in African individuals infected by HIV-1 non-B subtypes using HIV antibody avidity[J].Journal of clinical virology,2008,41(4):288-292.
[2] 龚渝蓉,徐梦娇,杨跃诚,等.德宏州2012—2015年婚检人群的HIV感染率及其影响因素[J].中国艾滋病性病,2017,23(5):405-408.
[3] UNAIDS Reference Group on Estimates Modelling and Projections.Statement on the use of the BED-assay for the estimation of HIV-1 incidence for surveillance or epidemic monitoring[J].WklyEpidemiol Rec,2006(81):40-41.
[4] Wei X,Liu X,Dobbs T,et al.Development of two avidity-based assays to detect recent HIV type 1 seroconversion using a multi-subtype gp41 recombinant protein[J].AIDS research and human retroviruses,2010,26(1):61-71.
[5] 中国疾病预防控制中心.全国艾滋病检测技术规范(2015年修订版)[J].中国病毒病杂志,2016,6(6):401-427.
[6] Duan S,Shen S,Bulterys M,et al.Estimation of HIV-1 incidence among five focal populations in Dehong,Yunnan:a hard hit area along a major drug trafficking route[J].BMC Public Health,2010,10(1):180.
[7] 罗小峰.德宏州饮酒与艾滋病相关高危行为及病程关系的流行病学研究[D].上海:复旦大学,2013.
[8] 段松,郭浩岩,庞琳,等.云南省德宏州艾滋病传播模式分析[J].中华预防医学杂志,2008,42(12):866-869.
[9] 段松,项丽芬,杨跃诚,等.云南省德宏州静脉注射毒品者HIV新发感染率及其危险因素研究[J].中华流行病学杂志,2009,30(12):1226-1229.
[10] Laeyendecker O,Brookmeyer R,Oliver AE,et al.Factors associated with incorrect identification of recent HIV infection using the BED capture immunoassay[J].AIDS research and human retroviruses,2012,28(8):816-822.
[11] Suligoi B,Buttò S,Galli C,et al.Detection of recent HIV infections in African individuals infected by HIV-1 non-B subtypes using HIV antibody avidity[J].Journal of clinical virology,2008,41(4):288-292.
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