磷酸肌酸钠治疗小儿肺炎支原体感染心肌损害效果评价
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摘要
目的评价磷酸肌酸钠治疗小儿肺炎支原体感染心肌损害的效果。方法将该院在2016年3月—2017年5月随机选取的70例肺炎支原体感染心肌损害的患儿作为对象,使用随机数表法将患者分为观察组(35例)和对照组(35例),两组均行常规治疗,观察组患儿在常规治疗的基础上使用磷酸肌酸钠进行治疗,对照组患儿在此基础上使用维生素C进行治疗,对比分析两组患者的疗效和各项指标的变化。结果观察组患儿的治疗总有效率为97.14%,对照组患儿的治疗总有效率为77.14%,观察组明显优于对照组(χ~2=6.247 7、P=0.012 4),呈临床不均衡性;治疗后两组患者的各指标水平均有所降低,观察组患者LDH(210.61±46.88)U/L、AST(22.13±13.70)U/L、CK-MB (17.60±7.32)U/L及肌钙蛋白(0.11±0.05)U/L降低水平与对照组LDH (265.05±48.27)U/L、AST (29.44±14.41)U/L、CK-MB(24.04±7.49)U/L及肌钙蛋白(0.25±0.08)U/L指标相比更明显,差异有统计学意义(P<0.05)。结论磷酸肌酸钠治疗小儿肺炎支原体感染心肌损害的效果较好,患儿各项指标的水平有所降低,具有较大的临床推广价值。
Objective To evaluate the effect of creatine phosphate sodium in treatment of children with myocardial damage of children with mycoplasma pneumoniae infection. Methods 70 cases of children with mycoplasma pneumoniae infection myocardial damage admitted and treated in our hospital from March 2016 to May 2017 were selected and randomly divided into two groups with 35 cases in each, both groups used the routine therapy, while the observation group were treated with creatine phosphate sodium, and the control group were treated with vitamin C, and the curative effect and changes of various indicators were analyzed and compared. Results The total treatment effective rate in the observation group were obviously better than those in the control group 97.14% vs 77.14%,(χ~2=6.2477, P=0.0124), with clinical unbalance; after treatment, the levels of various indicators of the two groups decreased, and the decrease levels of LDH(210.61±46.88)U/L, AST(22.13±13.70)U/L, CK-MB(17.60±7.32)U/L and troponin(0.11±0.05)U/L decreased compared with those in the control group LDH(265.05±48.27)U/L, AST(29.44±14.41)U/L, CK-MB(24.04±7.49)U/L and troponin(0.25±0.08)U/L, and the differences were statically significant(P<0.05). Conclusion The effect of creatine phosphate sodium in treatment of children with myocardial damage of children with mycoplasma pneumoniae infection is better, which can decrease the levels of various indicators, and it is of great promotion and application value.
Objective To evaluate the effect of creatine phosphate sodium in treatment of children with myocardial damage of children with mycoplasma pneumoniae infection. Methods 70 cases of children with mycoplasma pneumoniae infection myocardial damage admitted and treated in our hospital from March 2016 to May 2017 were selected and randomly divided into two groups with 35 cases in each, both groups used the routine therapy, while the observation group were treated with creatine phosphate sodium, and the control group were treated with vitamin C, and the curative effect and changes of various indicators were analyzed and compared. Results The total treatment effective rate in the observation group were obviously better than those in the control group 97.14% vs 77.14%,(χ~2=6.2477, P=0.0124), with clinical unbalance; after treatment, the levels of various indicators of the two groups decreased, and the decrease levels of LDH(210.61±46.88)U/L, AST(22.13±13.70)U/L, CK-MB(17.60±7.32)U/L and troponin(0.11±0.05)U/L decreased compared with those in the control group LDH(265.05±48.27)U/L, AST(29.44±14.41)U/L, CK-MB(24.04±7.49)U/L and troponin(0.25±0.08)U/L, and the differences were statically significant(P<0.05). Conclusion The effect of creatine phosphate sodium in treatment of children with myocardial damage of children with mycoplasma pneumoniae infection is better, which can decrease the levels of various indicators, and it is of great promotion and application value.
引文
[1]张磊.磷酸肌酸钠治疗小儿肺炎支原体感染心肌损害用药效果初评[J].中国现代药物应用,2016,10(1):112-113.
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[6]徐惠梅,张宝华,王锐.磷酸肌酸钠在小儿肺炎合并心力衰竭治疗的临床疗效观察[J].齐齐哈尔医学院学报,2013, 34(18):2708-2709.
[7]赵久龄,王玉水,王志华,等.清肺通络合剂对儿童肺炎支原体肺炎心肌酶谱的影响[J].中国实验方剂学杂志,2014, 20(12):209-211.
[8]张焯文,刘懿,赵炜堒.磷酸肌酸钠和果糖二磷酸钠治疗小儿重症肺炎合并心肌损伤的效果比较[J].内科, 2017,12(2):245-246.
[9]李伟,阴怀清.磷酸肌酸钠治疗小儿肺炎心肌损害的疗效分析[J].心理医生, 2016, 22(34):144-145.
[10]冯媛元.左卡尼汀治疗小儿支原体肺炎合并心肌损害效果研究[J].社区医学杂志, 2013, 11(7):8-9.
[2]董健,刘娜,马宝成.磷酸肌酸钠治疗小儿肺炎支原体感染心肌损害临床效果初评[J].中国继续医学教育,2015,7(23):150-151.
[3]朱振君,宋桂玲,冮铁成,等.磷酸肌酸钠与维生素C对肺炎支原体感染心肌损害患儿炎症因子水平的影响[J].现代生物医学进展,2016,16(30):5926-5929.
[4]张雪青.冻干丹参治疗小儿肺炎支原体感染并心肌损害的疗效观察[J].中国医药指南,2015,13(13):214-215.
[5]高伟红,康智禹.磷酸肌酸联合阿奇霉素治疗肺炎支原体肺炎并心肌损害40例[J].中国药业,2015,24(23):206-207.
[6]徐惠梅,张宝华,王锐.磷酸肌酸钠在小儿肺炎合并心力衰竭治疗的临床疗效观察[J].齐齐哈尔医学院学报,2013, 34(18):2708-2709.
[7]赵久龄,王玉水,王志华,等.清肺通络合剂对儿童肺炎支原体肺炎心肌酶谱的影响[J].中国实验方剂学杂志,2014, 20(12):209-211.
[8]张焯文,刘懿,赵炜堒.磷酸肌酸钠和果糖二磷酸钠治疗小儿重症肺炎合并心肌损伤的效果比较[J].内科, 2017,12(2):245-246.
[9]李伟,阴怀清.磷酸肌酸钠治疗小儿肺炎心肌损害的疗效分析[J].心理医生, 2016, 22(34):144-145.
[10]冯媛元.左卡尼汀治疗小儿支原体肺炎合并心肌损害效果研究[J].社区医学杂志, 2013, 11(7):8-9.